A common enzyme connects Notch signaling and Alzheimer's disease

被引:187
作者
Kopan, R [1 ]
Goate, A
机构
[1] Washington Univ, Sch Med, Dept Mol Biol & Pharmacol, St Louis, MO 63110 USA
[2] Washington Univ, Sch Med, Dept Psychiat, St Louis, MO 63110 USA
[3] Washington Univ, Sch Med, Dept Genet, St Louis, MO 63110 USA
关键词
D O I
10.1101/gad.836900
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
[No abstract available]
引用
收藏
页码:2799 / 2806
页数:8
相关论文
共 80 条
[1]   Notch signaling: Cell fate control and signal integration in development [J].
Artavanis-Tsakonas, S ;
Rand, MD ;
Lake, RJ .
SCIENCE, 1999, 284 (5415) :770-776
[2]  
Baumeister R, 1997, Genes Funct, V1, P149
[3]   Developmental regulation of presenilin mRNA expression parallels notch expression [J].
Berezovska, O ;
Xia, MQ ;
Page, K ;
Wasco, W ;
Tanzi, RE ;
Hyman, BT .
JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY, 1997, 56 (01) :40-44
[4]   A novel proteolytic cleavage involved in Notch signaling:: The role of the disintegrin-metalloprotease TACE [J].
Brou, C ;
Logeat, F ;
Gupta, N ;
Bessia, C ;
LeBail, O ;
Doedens, JR ;
Cumano, A ;
Roux, P ;
Black, RA ;
Israël, A .
MOLECULAR CELL, 2000, 5 (02) :207-216
[5]   Regulated intramembrane proteolysis: A control mechanism conserved from bacteria to humans [J].
Brown, MS ;
Ye, J ;
Rawson, RB ;
Goldstein, JL .
CELL, 2000, 100 (04) :391-398
[6]   Evidence that tumor necrosis factor α converting enzyme is involved in regulated α-secretase cleavage of the Alzheimer amyloid protein precursor [J].
Buxbaum, JD ;
Liu, KN ;
Luo, YX ;
Slack, JL ;
Stocking, KL ;
Peschon, JJ ;
Johnson, RS ;
Castner, BJ ;
Cerretti, DP ;
Black, RA .
JOURNAL OF BIOLOGICAL CHEMISTRY, 1998, 273 (43) :27765-27767
[7]   Presenilin-1 differentially facilitates endoproteolysis of the β-amyloid precursor protein and Notch [J].
Capell, A ;
Steiner, H ;
Romig, H ;
Keck, S ;
Baader, M ;
Grim, MG ;
Baumeister, R ;
Haass, C .
NATURE CELL BIOLOGY, 2000, 2 (04) :205-211
[8]  
De Strooper B, 2000, J CELL SCI, V113, P1857
[9]   A presenilin-1-dependent γ-secretase-like protease mediates release of Notch intracellular domain [J].
De Strooper, B ;
Annaert, W ;
Cupers, P ;
Saftig, P ;
Craessaerts, K ;
Mumm, JS ;
Schroeter, EH ;
Schrijvers, V ;
Wolfe, MS ;
Ray, WJ ;
Goate, A ;
Kopan, R .
NATURE, 1999, 398 (6727) :518-522
[10]   Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein [J].
De Strooper, B ;
Saftig, P ;
Craessaerts, K ;
Vanderstichele, H ;
Guhde, G ;
Annaert, W ;
Von Figura, K ;
Van Leuven, F .
NATURE, 1998, 391 (6665) :387-390