In vitro evaluation of the cytotoxic, hemolytic and clastogenic activities of Rhizostoma pulmo toxin(s)

被引：27

作者：

Allavena, A

Mariottini, GL

Carli, AM

Contini, S

Martelli, A ^{[1
]}

机构：

[1] Univ Genoa, Dept Internal Med, Pharmacol & Toxicol Unit, I-16132 Genoa, Italy

[2] Univ Genoa, Inst Environm Marine Sci, I-16132 Genoa, Italy

来源：

TOXICON | 1998年 / 36卷 / 06期

关键词：

D O I：

10.1016/S0041-0101(97)00171-2

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Cytotoxic, hemolytic and clastogenic activities of Rhizostoma pulmo toxin(s) contained in the jelly tissue free of nematocysts were investigated in mammalian cells with in vitro procedures. At the concentration of 37.6 mu g/ml the tissue protein produced the death of 50% V79 cells, a similar potency was observed in terms of hemolytic activity. The toxin(s) was not clastogenic for human lymphocytes in culture at the concentration of 5 mu g/ml. (C) 1998 Elsevier Science Ltd. All rights reserved.

引用

页码：933 / 936

页数：4

共 11 条

[1] STRUCTURE ACTIVITY RELATIONSHIP (SAR) MODELS ESTABLISHED INVITRO WITH THE NEUTRAL RED CYTOTOXICITY ASSAY [J].