Genetic structure and contrasting selection pattern at two major histocompatibility complex genes in wild house mouse populations

被引:23
作者
Cizkova, D. [1 ]
de Bellocq, J. Gouy [2 ]
Baird, S. J. E. [3 ]
Pialek, J. [1 ]
Bryja, J. [1 ]
机构
[1] Acad Sci Czech Republ, Inst Vertebrate Biol, Dept Populat Biol, Brno, Czech Republic
[2] Univ Antwerp, Evolutionary Ecol Grp, B-2020 Antwerp, Belgium
[3] Univ Porto, Ctr Invest Biodiversidade & Recursos Genet, CIBIO, P-4100 Oporto, Portugal
关键词
MHC; house mouse; selection; population structure; trans-species polymorphism; CLASS-II GENES; BALANCING SELECTION; MUS-MUSCULUS; CRYSTAL-STRUCTURE; MHC; POLYMORPHISM; EVOLUTION; RECOMBINATION; ORIGIN; MICE;
D O I
10.1038/hdy.2010.112
中图分类号
Q14 [生态学(生物生态学)];
学科分类号
071012 ; 0713 ;
摘要
The mammalian major histocompatibility complex (MHC) is a tightly linked cluster of immune genes, and is often thought of as inherited as a unit. This has led to the hope that studying a single MHC gene will reveal patterns of evolution representative of the MHC as a whole. In this study we analyse a 1000-km transect of MHC variation traversing the European house mouse hybrid zone to compare signals of selection and patterns of diversification at two closely linked MHC class II genes, H-2Aa and H-2Eb. We show that although they are 0.01cM apart (that is, recombination is expected only once in 10 000 meioses), disparate evolutionary patterns were detected. H-2Aa shows higher allelic polymorphism, faster allelic turnover due to higher mutation rates, stronger positive selection at antigen-binding sites and higher population structuring than H-2Eb. H-2Eb alleles are maintained in the gene pool for longer, including over separation of the subspecies, some H-2Eb alleles are positively and others negatively selected and some of the alleles are not expressed. We conclude that studies on MHC genes in wild-living vertebrates can give substantially different results depending on the MHC gene examined and that the level of polymorphism in a related species is a poor criterion for gene choice. Heredity (2011) 106, 727-740; doi:10.1038/hdy.2010.112; published online 8 September 2010
引用
收藏
页码:727 / 740
页数:14
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