Copper-Catalyzed Trifluoromethylation of Aryl and Vinyl Boronic Acids with An Electrophilic Trifluoromethylating Reagent

被引：278
作者：
Liu, Tianfei [1 ]
Shen, Qilong [1 ]
机构：
[1] Chinese Acad Sci, Shanghai Inst Organ Chem, Key Lab Organofluorine Chem, Shanghai 200032, Peoples R China
来源：
ORGANIC LETTERS | 2011年 / 13卷 / 09期
基金：
中国国家自然科学基金;
关键词：
REDUCTIVE ELIMINATION; MEDICINAL CHEMISTRY; ARENES; IODINE; ORGANOSTANNANES; BORYLATION; CYANATION; HALIDES; IODANES; AGENT;
D O I：
10.1021/ol2005903
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A copper-catalyzed trifluoromethylation of aryl- and alkenylboronic acids with Togni's reagent was described. The reaction proceeded in good to excellent yields for a range of different substrates including heteroarylboronic acids and substrates with a variety of functional groups under mild reaction conditions.
引用
收藏
页码：2342 / 2345
页数：4
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