Impact of Visceral Obesity on Microvascular Invasion in Hepatocellular Carcinoma

被引：6

作者：

Arsenii, Nicolae ^{[1
]}

Piardi, Tullio ^{[2
]}

Diebold, Marie-Daniele ^{[3
]}

Chenard, Marie-Pierrette ^{[4
]}

Drame, Moustapha ^{[5
]}

De Mestier, Louis ^{[1
]}

Hoeffel, Christine ^{[6
]}

Pessaux, Patrick ^{[7
]}

Sommacale, Daniele ^{[2
]}

Thiefin, Gerard ^{[1
]}

机构：

[1] Reims Univ Hosp, Dept Hepatogastroenterol, Reims, France

[2] Reims Univ Hosp, Dept Gen Digest & Endocrine Surg, Reims, France

[3] Reims Univ Hosp, Dept Biopathol, Reims, France

[4] Univ Hosp Strasbourg, Dept Histopathol, Strasbourg, France

[5] Reims Univ Hosp, Dept Res & Innovat, Reims, France

[6] Reims Univ Hosp, Dept Radiol, Reims, France

[7] Univ Hosp Strasbourg, Dept Digest Surg, Strasbourg, France

来源：

CANCER INVESTIGATION | 2016年 / 34卷 / 06期

关键词：

Liver and Billary System Cancer; Angiogenesis; Invasion and Metastasis; Visceral obesity; INTRAHEPATIC RECURRENCE; LIVER-TRANSPLANTATION; RISK-FACTORS; VASCULAR INVASION; ALPHA-FETOPROTEIN; VENOUS INVASION; TUMOR SIZE; RESECTION; CANCER; HEPATECTOMY;

D O I：

10.1080/07357907.2016.1193747

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Background. Our objective was to determine whether visceral obesity is associated with increased microvascular invasion (MVI) in patients surgically treated for hepatocellular carcinoma (HCC). Methods. Data were collected retrospectively in a series of 79 patients treated by surgical resection for HCC, using CT-scan for evaluation of visceral obesity. Results. There was no significant association between visceral obesity and MVI (OR = 1.20 (0.38-3.75), p = 0.75). Independent predictive factors of MVI were moderate/poor differentiation, tumor size above 50mm and underlying cirrhosis. Conclusion. This study did not support the hypothesis that visceral obesity might promote MVI in patients with HCC.

引用

页码：271 / 278

页数：8

共 53 条

[31] Preoperative assessment of hepatocellular carcinoma tumor grade using needle biopsy - Implications for transplant eligibility [J].

Pawlik, Timothy M. ;

Gleisner, Ana L. ;

Anders, Robert A. ;

Assumpcao, Lia ;

Maley, Warren ;

Choti, Michael A. .

ANNALS OF SURGERY, 2007, 245 (03) :435-442

[32] Tumor size predicts vascular invasion and histologic grade: Implications for selection of surgical treatment for hepatocellular carcinoma [J].

Pawlik, TM ;

Delman, KA ;

Vauthey, JN ;

Nagorney, DM ;

Ng, IOL ;

Ikai, I ;

Yamaoka, Y ;

Belghiti, J ;

Lauwers, GY ;

Poon, RT ;

Abdalla, EK .

LIVER TRANSPLANTATION, 2005, 11 (09) :1086-1092

[33]

Poon RTP, 2000, CANCER, V89, P500, DOI 10.1002/1097-0142(20000801)89:3<500::AID-CNCR4>3.3.CO

[34]

2-F

[35] Early and late recurrence after liver resection for hepatocellular carcinoma - Prognostic and therapeutic implications [J].

Portolani, N ;

Coniglio, A ;

Ghidoni, S ;

Giovanelli, M ;

Benetti, A ;

Tiberio, GAM ;

Giulini, SM .

ANNALS OF SURGERY, 2006, 243 (02) :229-235

[36] Prevalence and clinical implications of sarcopenic obesity in patients with solid tumours of the respiratory and gastrointestinal tracts: a population-based study [J].

Prado, Carla M. M. ;

Liefers, Jessica R. ;

McCargar, Linda J. ;

Reiman, Tony ;

Sawyer, Michael B. ;

Martin, Lisa ;

Baracos, Vickie E. .

LANCET ONCOLOGY, 2008, 9 (07) :629-635

[37] A System of Classifying Microvascular Invasion to Predict Outcome After Resection in Patients With Hepatocellular Carcinoma [J].

Roayaie, Sasan ;

Blume, Iris N. ;

Thung, Swan N. ;

Guido, Maria ;

Fiel, Maria-Isabel ;

Hiotis, Spiros ;

Labow, Daniel M. ;

Llovet, Josep M. ;

Schwartz, Myron E. .

GASTROENTEROLOGY, 2009, 137 (03) :850-855

[38] A Systematic Review of Microvascular Invasion in Hepatocellular Carcinoma: Diagnostic and Prognostic Variability [J].

Rodriguez-Peralvarez, Manuel ;

Tu Vinh Luong ;

Andreana, Lorenzo ;

Meyer, Tim ;

Dhillon, Amar Paul ;

Burroughs, Andrew Kenneth .

ANNALS OF SURGICAL ONCOLOGY, 2013, 20 (01) :325-339

[39] Recurrence after liver resection for hepatocellular carcinoma: Risk factors, treatment, and outcomes [J].

Shah, Shimul A. ;

Cleary, Sean P. ;

Wei, Alice C. ;

Yang, Ilun ;

Taylor, Bryce R. ;

Hemming, Alan W. ;

Langer, Bernard ;

Grant, David R. ;

Greig, Paul D. ;

Gallinger, Steven .

SURGERY, 2007, 141 (03) :330-339

[40] The predictors of microvascular invasion in candidates for liver transplantation with hepatocellular carcinoma - With special reference to the serum levels of des-gamma-carboxy prothrombin [J].

Shirabe, Ken ;

Itoh, Shinji ;

Yoshizumi, Tomoharu ;

Soejima, Yuji ;

Taketomi, Akinobu ;

Aishima, Shin-Ichi ;

Maehara, Yoshihiko .

JOURNAL OF SURGICAL ONCOLOGY, 2007, 95 (03) :235-240

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