Decreased absolute numbers of CD3+ T cells and CD8+ T cells during aging in herpes zoster patients

被引：21
作者：
Wei, Li [1 ]
Zhao, Jianguang [3 ]
Wu, Wei [1 ]
Zhang, Yu [4 ]
Fu, Xuyan [1 ]
Chen, Lifeng [4 ]
Wang, Xiaoting [2 ]
机构：
[1] Zhejiang Univ, Sch Med,Affiliated Hosp 1, State Key Lab Diagnost & Treatment Infect Dis, Collaborat Innovat Ctr Diag & Treatment Infect Di, Hangzhou, Zhejiang, Peoples R China
[2] Zhejiang Univ, Sch Med, Affiliated Hosp 1, Med Oncol, Hangzhou, Zhejiang, Peoples R China
[3] Dermatovenereol Hosp, Dept Dermatol, Quzhou, Peoples R China
[4] Zhejiang Univ, Sch Med, Affiliated Hosp 1, Dept Dermatol, Hangzhou, Zhejiang, Peoples R China
来源：
SCIENTIFIC REPORTS | 2017年 / 7卷
基金：
中国国家自然科学基金;
关键词：
VIRUS; RESPONSES; CD4(+); MEMORY; REACTIVATION; RECOGNITION; GENERATION;
D O I：
10.1038/s41598-017-15390-w
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Herpes zoster (HZ) is an infectious dermatosis with high incidence worldwide. Age is a key risk factor for HZ, and postherpetic neuralgia (PHN) is the main sequelae. Until now, no index has been available to predict the pathogenesis of PHN, and rare reports have focused on the immune response during aging and PHN. In this study, we selected immunoglobulin and complement proteins as markers for humoral immunity, while T lymphocyte subsets and natural killer (NK) cells were selected as markers for cell immunity, to systematically study the characteristics of immune responses in the peripheral blood of HZ patients. Our data showed that the absolute number of CD3(+) T cells and CD8(+) T cells decreased during aging and PHN. This implies that more attention should be paid to prevent the occurrence of PHN, especially in the aged population.
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页数：8
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