Natalizumab therapy of multiple sclerosis: recommendations of the Multiple Sclerosis Study Group-Italian Neurological Society

被引：15

作者：

Ghezzi, A. ^{[1
]}

Grimaldi, L. M. E. ^{[2
]}

Marrosu, M. G. ^{[3
]}

Pozzilli, C. ^{[4
]}

Comi, G. ^{[5
]}

Bertolotto, A. ^{[6
,28
]}

Trojano, M. ^{[7
]}

Gallo, P. ^{[8
]}

Capra, R. ^{[9
]}

Centonze, D. ^{[10
]}

Millefiorini, E. ^{[11
]}

Sotgiu, S. ^{[12
]}

Morra, V. Brescia ^{[13
]}

Amato, M. P. ^{[14
]}

Lugaresi, A. ^{[15
]}

Mancardi, G. ^{[16
]}

Caputo, D. ^{[17
]}

Montanari, E. ^{[18
]}

Provinciali, L. ^{[19
]}

Durelli, L. ^{[20
]}

Bergamaschi, R. ^{[21
]}

Bellantonio, P. ^{[22
]}

Tola, M. R. ^{[23
]}

Cottone, S. ^{[24
]}

Savettieri, G. ^{[25
]}

Tedeschi, G. ^{[26
,27
]}

机构：

[1] Osped Gallarate, Ctr Studi Sclerosi Multipla, UO Neurol 2, Gallarate, Italy

[2] Fdn Ist San Raffaele G Giglio, UO Neurol, Palermo, Italy

[3] Univ Cagliari, Ctr Sclerosi Multipla & Clin Neurol, Cagliari, Italy

[4] Univ Roma La Sapienza, Osped S Andrea, Ctr Sclerosi Multipla, Rome, Italy

[5] Univ Milan, Osped San Raffaele, Dipartimento Neurol, Ist Sci Univ, I-20127 Milan, Italy

[6] AOUS Luigi Gonzaga, Ctr Riferimento Reg Sclerosi Multipla CRESM, Turin, Italy

[7] Policlin Univ Bari, Dipartimento Sci Neurol & Psichiat, Bari, Italy

[8] AO Univ Padova, Ctr Riferimento Reg Sclerosi Multipla, Padua, Italy

[9] Spedali Civil Brescia, Ctr Riferimento Sclerosi Multipla, USD Neurol, I-25125 Brescia, Italy

[10] Univ Roma Tor Vergata, Dipartimento Neurosci, Neurol Clin, Rome, Italy

[11] Univ Roma La Sapienza, Dipartimento Sci Neurol, Cattedra Clin Neurol 3, I-00185 Rome, Italy

[12] Univ Sassari, Ist Clin Neurol, I-07100 Sassari, Italy

[13] Univ Naples Federico II, Dipartimento Sci Neurol, Naples, Italy

[14] Univ Florence, Dipartimento Sci Neurol & Psichiat, Clin Neurol 1, Florence, Italy

[15] Univ G dAnnunzio, Dipartimento Neurosci & Immagini, Chieti, Italy

[16] Univ Genoa, Neurol Clin 2, Dipartimento Neurosci Oftalmol & Genet, Genoa, Italy

[17] Ctr IRCCS S Maria Nascente Fdn Don Gnocchi, Milan, Italy

[18] Univ Parma, Neurol Clin, UO Neurol, I-43100 Parma, Italy

[19] Univ Politecn Marche, AOU Osped Riuniti, Neurol Clin, Ancona, Italy

[20] Osped S Luigi Gonzaga, Div Neurol, Turin, Italy

[21] IRCCS Fdn Ist Neurol Nazl C Mondino, Ctr Sclerosi Multipla, Pavia, Italy

[22] Ctr Sclerosi Multipla IRCCS Neuromed, Dipartimento Neurol, Pozzilli, Isernia, Italy

[23] AOU Arcispedale St Anna, UO Neurol, Dipartimento Neurosci Riabilitaz, Ferrara, Italy

[24] AO Villa Sofia CTO, UO Neurol, Palermo, Italy

[25] Univ Palermo, Dipartimento Univ Neurosci Clin, Palermo, Italy

[26] Univ Naples 2, Dipartimento Sci Neurol, Naples, Italy

[27] Ist Hermitage Capodimonte, Naples, Italy

[28] AOUS Luigi Gonzaga, Neurobiol Clin, Turin, Italy

来源：

NEUROLOGICAL SCIENCES | 2011年 / 32卷 / 02期

关键词：

Multiple sclerosis; Natalizumab; PML; IRIS; PROGRESSIVE MULTIFOCAL LEUKOENCEPHALOPATHY; EFFICACY; DISEASE; SAFETY;

D O I：

10.1007/s10072-010-0469-0

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Three years after the introduction of natalizumab (NA) therapy for the second line treatment of relapsing-remitting multiple sclerosis (MS), Italian MS centers critically reviewed the scientific literature and their own clinical experience. Natalizumab was shown to be highly efficaciuos in the treatment of MS. However, the risk of progressive multifocal leukoencephalopathy was confirmed and defined better. This article summarizes the MS-SIN Study Group recommendations on the use of NA in MS, with particular reference to the appropriate selection and monitoring of patients as well as to the management of adverse events.

引用

页码：351 / 358

页数：8

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