Molecular Biology and Immunology of Head and Neck Cancer

被引：28

作者：

Guo, Theresa ^{[1
]}

Califano, Joseph A. ^{[1
]}

机构：

[1] Johns Hopkins Med Inst, Dept Otolaryngol Head & Neck Surg, Baltimore, MD 21231 USA

来源：

SURGICAL ONCOLOGY CLINICS OF NORTH AMERICA | 2015年 / 24卷 / 03期

关键词：

Molecular biology; Targeted therapy; Immunology; Head and neck cancer; SQUAMOUS-CELL CARCINOMA; RANDOMIZED PHASE-II; GENE COPY NUMBER; HUMAN-PAPILLOMAVIRUS; RADIATION RESPONSE; TP53; MUTATIONS; P53; GENE; RECURRENT; SURVIVAL; INHIBITION;

D O I：

10.1016/j.soc.2015.03.002

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

In recent years, our knowledge and understanding of head and neck squamous cell carcinoma (HNSCC) has expanded dramatically. New high-throughput sequencing technologies have accelerated these discoveries since the first reports of whole-exome sequencing of HNSCC tumors in 2011. In addition, the discovery of human papillomavirus in relationship with oropharyngeal squamous cell carcinoma has shifted our molecular understanding of the disease. New investigation into the role of immune evasion in HNSCC has also led to potential novel therapies based on immune-specific systemic therapies.

引用

页码：397 / +

页数：12

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