MicroRNA as an Important Target for Anticancer Drug Development

被引：95
作者：
Fu, Zhiwen [1 ,2 ]
Wang, Liu [1 ,2 ]
Li, Shijun [1 ,2 ]
Chen, Fen [1 ,2 ]
Au-Yeung, Kathy Ka-Wai [3 ]
Shi, Chen [1 ,2 ]
机构：
[1] Huazhong Univ Sci & Technol, Union Hosp, Tongji Med Coll, Dept Pharm, Wuhan, Peoples R China
[2] Hubei Prov Clin Res Ctr Precis Med Crit Illness, Wuhan, Peoples R China
[3] St Boniface Hosp Res Ctr, Winnipeg, MB, Canada
来源：
FRONTIERS IN PHARMACOLOGY | 2021年 / 12卷
基金：
中国国家自然科学基金;
关键词：
microRNA; anticancer therapeutics; drug target; MiRNA mimics; antagomirs; oncomirs; tumor suppressor miRNAs; BREAST-CANCER CELLS; HEPATOCELLULAR-CARCINOMA CELLS; CANDIDATE TUMOR-SUPPRESSOR; SMALL-MOLECULE INHIBITORS; PROSTATE-CANCER; REPLACEMENT THERAPY; PROMOTES MIGRATION; MIRNA BIOGENESIS; DOWN-REGULATION; CYCLE ARREST;
D O I：
10.3389/fphar.2021.736323
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Cancer has become the second greatest cause of death worldwide. Although there are several different classes of anticancer drugs that are available in clinic, some tough issues like side-effects and low efficacy still need to dissolve. Therefore, there remains an urgent need to discover and develop more effective anticancer drugs. MicroRNAs (miRNAs) are a class of small endogenous non-coding RNAs that regulate gene expression by inhibiting mRNA translation or reducing the stability of mRNA. An abnormal miRNA expression profile was found to exist widely in cancer cell, which induces limitless replicative potential and evading apoptosis. MiRNAs function as oncogenes (oncomiRs) or tumor suppressors during tumor development and progression. It was shown that regulation of specific miRNA alterations using miRNA mimics or antagomirs can normalize the gene regulatory network and signaling pathways, and reverse the phenotypes in cancer cells. The miRNA hence provides an attractive target for anticancer drug development. In this review, we will summarize the latest publications on the role of miRNA in anticancer therapeutics and briefly describe the relationship between abnormal miRNAs and tumorigenesis. The potential of miRNA-based therapeutics for anticancer treatment has been critically discussed. And the current strategies in designing miRNA targeting therapeutics are described in detail. Finally, the current challenges and future perspectives of miRNA-based therapy are conferred.</p>
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页数：18
相关论文
共 208 条
[1]  
Alizadeh S., 2020, J BASIC RES MED SCI, V7, P47
[2]   Cobomarsen, an Oligonucleotide Inhibitor of miR-155, Slows DLBCL Tumor Cell Growth In Vitro and In Vivo [J].
Anastasiadou, Eleni ;
Seto, Anita G. ;
Beatty, Xuan ;
Hermreck, Melanie ;
Gilles, Maud-Emmanuelle ;
Stroopinsky, Dina ;
Pinter-Brown, Lauren C. ;
Pestano, Linda ;
Marchese, Cinzia ;
Avigan, David ;
Trivedi, Pankaj ;
Escolar, Diana M. ;
Jackson, Aimee L. ;
Slack, Frank J. .
CLINICAL CANCER RESEARCH, 2021, 27 (04) :1139-1149
[3]   miR-15a and miR-16-1 in cancer: discovery, function and future perspectives [J].
Aqeilan, R. I. ;
Calin, G. A. ;
Croce, C. M. .
CELL DEATH AND DIFFERENTIATION, 2010, 17 (02) :215-220
[4]   MicroRNA-21 (miR-21) post-transcriptionally downregulates tumor suppressor Pdcd4 and stimulates invasion, intravasation and metastasis in colorectal cancer [J].
Asangani, I. A. ;
Rasheed, S. A. K. ;
Nikolova, D. A. ;
Leupold, J. H. ;
Colburn, N. H. ;
Post, S. ;
Allgayer, H. .
ONCOGENE, 2008, 27 (15) :2128-2136
[5]   Molecular identification of miR-145 and miR-9 expression level as prognostic biomarkers for early-stage cervical cancer detection [J].
Azizmohammadi, S. ;
Safari, A. ;
Azizmohammadi, S. ;
Kaghazian, M. ;
Sadrkhanlo, M. ;
Yahaghi, E. ;
Farshgar, R. ;
Seifoleslami, M. .
QJM-AN INTERNATIONAL JOURNAL OF MEDICINE, 2017, 110 (01) :11-15
[6]   Developing therapeutic microRNAs for cancer [J].
Bader, A. G. ;
Brown, D. ;
Stoudemire, J. ;
Lammers, P. .
GENE THERAPY, 2011, 18 (12) :1121-1126
[7]  
Bader Andreas G., 2012, Frontiers in Genetics, V3, P120, DOI 10.3389/fgene.2012.00120
[8]   A TrkB-STAT3-miR-204-5p regulatory circuitry controls proliferation and invasion of endometrial carcinoma cells [J].
Bao, Wei ;
Wang, Hui-Hui ;
Tian, Fu-Ju ;
He, Xiao-Ying ;
Qiu, Mei-Ting ;
Wang, Jing-Yun ;
Zhang, Hui-Juan ;
Wang, Li-Hua ;
Wan, Xiao-Ping .
MOLECULAR CANCER, 2013, 12
[9]  
Barrette-Lee P., 2009, ADV BREAST CANC, V6, P24
[10]   MicroRNAs: Target Recognition and Regulatory Functions [J].
Bartel, David P. .
CELL, 2009, 136 (02) :215-233
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