The premature ageing syndrome protein, WRN, is a 3′→5′ exonuclease

被引：355

作者：

Huang, SR

Li, BM

Gray, MD

Oshima, J

Mian, SI

Campisi, J ^{[1
]}

机构：

[1] Univ Calif Berkeley, Lawrence Berkeley Lab, Div Cell & Mol Biol, Berkeley, CA 94720 USA

[2] Univ Washington, Dept Pathol, Seattle, WA 98195 USA

[3] Univ Calif Berkeley, Lawrence Berkeley Lab, Dept Radiat Biol, Berkeley, CA 94720 USA

来源：

NATURE GENETICS | 1998年 / 20卷 / 02期

关键词：

D O I：

10.1038/2410

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

引用

页码：114 / 116

页数：3

共 14 条

[1] HOMOLOGOUS RECOMBINATION IS ELEVATED IN SOME WERNER-LIKE SYNDROMES BUT NOT DURING NORMAL INVITRO OR INVIVO SENESCENCE OF MAMMALIAN-CELLS [J].

CHENG, RZ ;

MURANO, S ;

KURZ, B ;

REIS, RJS .

MUTATION RESEARCH, 1990, 237 (5-6) :259-269

[2] MUTATOR PHENOTYPE OF WERNER SYNDROME IS CHARACTERIZED BY EXTENSIVE DELETIONS [J].

FUKUCHI, K ;

MARTIN, GM ;

MONNAT, RJ .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1989, 86 (15) :5893-5897

[3] BLOOM-SYNDROME - A MENDELIAN PROTOTYPE OF SOMATIC MUTATIONAL DISEASE [J].

GERMAN, J .

MEDICINE, 1993, 72 (06) :393-406

[4] Hierarchical deterioration of body systems in Werner's syndrome: Implications for normal ageing [J].

Goto, M .

MECHANISMS OF AGEING AND DEVELOPMENT, 1997, 98 (03) :239-254

[5] The Werner syndrome protein is a DNA helicase [J].

Gray, MD ;

Shen, JC ;

KamathLoeb, AS ;

Blank, A ;

Sopher, BL ;

Martin, GM ;

Oshima, J ;

Loeb, LA .

NATURE GENETICS, 1997, 17 (01) :100-103

[6]

MAIN IS, 1997, NUCLEIC ACIDS RES, V25, P3187

[7]

Martin G M, 1978, Birth Defects Orig Artic Ser, V14, P5

[8]

MARTIN GM, 1970, LAB INVEST, V23, P86

[9] Positionally cloned human disease genes: Patterns of evolutionary conservation and functional motifs [J].

Mushegian, AR ;

Bassett, DE ;

Boguski, MS ;

Bork, P ;

Koonin, EV .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1997, 94 (11) :5831-5836

[10] An apoptosis-inducing genotoxin differentiates heterozygotic carriers for Werner helicase mutations from wild-type and homozygous mutants [J].

Ogburn, CE ;

Oshima, J ;

Poot, M ;

Chen, R ;

Gollahon, KA ;

Rabinovitch, PS ;

Martin, GM .

HUMAN GENETICS, 1997, 101 (02) :121-125

← 1 2 →