Shell-sheddable micelles based on star-shaped poly(ε-caprolactone)-SS-poly(ethyl glycol) copolymer for intracellular drug release

被引：87
|
作者：
Ren, Tian-Bin [2 ]
Feng, Yue [2 ]
Zhang, Zhong-Hai [2 ]
Li, Lan [2 ]
Li, Yong-Yong [1 ]
机构：
[1] Tongji Univ, Inst Adv Mat & Nano Biomed, Shanghai 200092, Peoples R China
[2] Tongji Univ, Sch Mat Sci & Engn, Inst Nano & Biopolymer Mat, Shanghai 200092, Peoples R China
来源：
SOFT MATTER | 2011年 / 7卷 / 06期
关键词：
DELIVERY; STABILITY; STRATEGY;
D O I：
10.1039/c1sm05020f
中图分类号：
O64 [物理化学（理论化学）、化学物理学];
学科分类号：
070304 ; 081704 ;
摘要：
We report on the preparation and drug delivery application of shell sheddable micelles based on disulfide-linked star-shaped copolymer of poly(epsilon-caprolactone) and poly(ethyl glycol) (6sPCL-SS-PEG). Interestingly, the micelles exhibit high stability normally and rapid destabilization under a reduction environment, eliciting GSH dependent cytotoxicity of drug-loaded formulations on tumor cells.
引用
收藏
页码：2329 / 2331
页数：3
相关论文
共 50 条
  • [21] Star-shaped poly (Γ-caprolactone-b-ethylene glycol):: Synthesis, characterization and aggregation behavior
    Fan, Yujiang
    Liang, Jie
    Chen, Guoping
    Tateishi, Tetsuya
    Gu, Zhongwei
    Zhang, Xingdong
    ASBM7: ADVANCED BIOMATERIALS VII, 2007, 342-343 : 725 - +
  • [22] SYNTHESIS AND CHARACTERIZATION OF STAR-SHAPED POLY (ε-CAPROLACTONE)-b-POLY(2-HYDROXYETHYL METHACRYLATE) BLOCK COPOLYMER
    Wang Beilei
    Tu Song
    Qiu Yongbing
    Chen Yuanwei
    Luo Xianglin
    ACTA POLYMERICA SINICA, 2011, (10) : 1151 - 1156
  • [23] Solution crystallization behavior of linear and star-shaped poly(ethylene glycol)-b-poly(ɛ-caprolactone) block copolymers
    Ting Yu
    Jian-qiang Zhang
    Ya Li
    Su-dan Shen
    Wen-feng Wei
    Peng Chen
    Zong-bao Wang
    Qun Gu
    Chinese Journal of Polymer Science, 2013, 31 : 1717 - 1724
  • [24] pH-responsive star-shaped functionalized poly(ethylene glycol)-b-poly(ε-caprolactone) with amino groups
    Fu, Yutong
    Xia, Xinyu
    Zhang, Yan
    Ye, Jinhai
    Lang, Meidong
    COLLOID AND POLYMER SCIENCE, 2014, 292 (09) : 2071 - 2082
  • [25] pH-responsive star-shaped functionalized poly(ethylene glycol)-b-poly(ε-caprolactone) with amino groups
    Yutong Fu
    Xinyu Xia
    Yan Zhang
    Jinhai Ye
    Meidong Lang
    Colloid and Polymer Science, 2014, 292 : 2071 - 2082
  • [26] Solution crystallization behavior of linear and star-shaped poly(ethylene glycol)-b-poly(ε-caprolactone) block copolymers
    Yu, Ting
    Zhang, Jian-qiang
    Li, Ya
    Shen, Su-dan
    Wei, Wen-feng
    Chen, Peng
    Wang, Zong-bao
    Gu, Qun
    CHINESE JOURNAL OF POLYMER SCIENCE, 2013, 31 (12) : 1717 - 1724
  • [27] Preparation, characterization, and drug release behaviors of drug nimodipine-loaded poly(ε-caprolactone)-poly(ethylene oxide)-poly(ε-caprolactone) amphiphilic triblock copolymer micelles
    Ge, HX
    Hu, Y
    Jiang, XQ
    Cheng, DM
    Yuan, YY
    Bi, H
    Yang, CZ
    JOURNAL OF PHARMACEUTICAL SCIENCES, 2002, 91 (06) : 1463 - 1473
  • [28] Poly(lactic acid)/poly(ethylene glycol) block copolymer based shell or core cross-linked micelles for controlled release of hydrophobic drug
    Li, Junjie
    Guo, Shuangzhuang
    Wang, Min
    Ye, Lei
    Yao, Fanglian
    RSC ADVANCES, 2015, 5 (25) : 19484 - 19492
  • [29] Toolbox of Biodegradable Dendritic (Poly glycerol sulfate)-SS-poly(ester) Micelles for Cancer Treatment: Stability, Drug Release, and Tumor Targeting
    Braatz, Daniel
    Dimde, Mathias
    Ma, Guoxin
    Zhong, Yinan
    Tully, Michael
    Groetzinger, Carsten
    Zhang, Yuanyuan
    Mavroskoufis, Alexandros
    Schirner, Michael
    Zhong, Zhiyuan
    Ballauff, Matthias
    Haag, Rainer
    BIOMACROMOLECULES, 2021, 22 (06) : 2625 - 2640
  • [30] Complexation between poly(methacrylic) and poly(acrylic) acids and star-shaped poly(ethylene glycol) based on pyrogallol
    Baranovsky, VY
    Shenkov, S
    Doseva, V
    Borisov, G
    JOURNAL OF POLYMER SCIENCE PART A-POLYMER CHEMISTRY, 1996, 34 (11) : 2253 - 2258
12345