Shell-sheddable micelles based on star-shaped poly(ε-caprolactone)-SS-poly(ethyl glycol) copolymer for intracellular drug release

被引：87
|
作者：
Ren, Tian-Bin [2 ]
Feng, Yue [2 ]
Zhang, Zhong-Hai [2 ]
Li, Lan [2 ]
Li, Yong-Yong [1 ]
机构：
[1] Tongji Univ, Inst Adv Mat & Nano Biomed, Shanghai 200092, Peoples R China
[2] Tongji Univ, Sch Mat Sci & Engn, Inst Nano & Biopolymer Mat, Shanghai 200092, Peoples R China
来源：
SOFT MATTER | 2011年 / 7卷 / 06期
关键词：
DELIVERY; STABILITY; STRATEGY;
D O I：
10.1039/c1sm05020f
中图分类号：
O64 [物理化学（理论化学）、化学物理学];
学科分类号：
070304 ; 081704 ;
摘要：
We report on the preparation and drug delivery application of shell sheddable micelles based on disulfide-linked star-shaped copolymer of poly(epsilon-caprolactone) and poly(ethyl glycol) (6sPCL-SS-PEG). Interestingly, the micelles exhibit high stability normally and rapid destabilization under a reduction environment, eliciting GSH dependent cytotoxicity of drug-loaded formulations on tumor cells.
引用
收藏
页码：2329 / 2331
页数：3
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