IL-6 involvement in epithelial cancers

被引：229

作者：

Schafer, Zachary T. ^{[1
]}

Brugge, Joan S. ^{[1
]}

机构：

[1] Harvard Univ, Sch Med, Dept Cell Biol, Boston, MA 02115 USA

来源：

JOURNAL OF CLINICAL INVESTIGATION | 2007年 / 117卷 / 12期

关键词：

D O I：

10.1172/JCI34237

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

in this issue of the JCI, two reports provide intriguing new information on the role of the inflammatory cytokine IL-6 in breast and lung cancer. The study by Sansone et al. implicates IL-6 in the instigation of malignant properties in breast cancer stem cells (see the related article beginning on page 3988). The study by Gao, et al. identifies mutant variants of EGFR as inducers of IL-6 in lung adenocarcinomas (see the related article beginning on page 3846). These studies add to our understanding of potential roles for IL-6 in cancer and further motivate investigations of IL-6-targeted chemotherapeutics.

引用

页码：3660 / 3663

页数：4

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