Recent advances in aptamer-based nanosystems and microfluidics devices for the detection of ovarian cancer biomarkers

被引：23

作者：

Vandghanooni, Somayeh ^{[1
,2
]}

Sanaat, Zohreh ^{[1
]}

Barar, Jaleh ^{[2
,3
]}

Adibkia, Khosro ^{[2
,3
]}

Eskandani, Morteza ^{[2
]}

Omidi, Yadollah ^{[4
]}

机构：

[1] Tabriz Univ Med Sci, Hematol & Oncol Res Ctr, Tabriz, Iran

[2] Tabriz Univ Med Sci, Biomed Inst, Res Ctr Pharmaceut Nanotechnol, Tabriz, Iran

[3] Tabriz Univ Med Sci, Dept Pharmaceut, Fac Pharm, Tabriz, Iran

[4] Nova Southeastern Univ, Coll Pharm, Dept Pharmaceut Sci, Ft Lauderdale, FL 33314 USA

来源：

TRAC-TRENDS IN ANALYTICAL CHEMISTRY | 2021年 / 143卷

关键词：

Aptamers; Biosensors; Ovarian cancer diagnosis; CA-125; Microfluidics; CIRCULATING TUMOR-CELLS; ELECTROCHEMICAL SENSORS; CARBON NANOFIBERS; NUCLEIC-ACID; CA; 125; CA125; NANOPARTICLES; IMMUNOSENSOR; IMMUNOASSAY; IMMUNOTHERAPY;

D O I：

10.1016/j.trac.2021.116343

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

Cost-efficient sensitive detection of solid tumor markers in patients' serums with high accuracy and specificity has been a striking challenge. The early detection of ovarian cancer (OC) can significantly increase the survival rate of patients. Additional to the aptamer (Ap)-based electrochemical and optical sensors, microfabricated microfluidic-based biosensing systems continue to substantially advance the quantitative detection of molecular biomarkers of various detrimental diseases such as OC and other types of solid tumors. The use of advanced nanobiomaterials has resulted in the development of sophisticated smart sensors that have been employed for the detection of OC molecular markers, including several cancer antigens (e.g., CA-125, CA-15), exosomes, and even blood circulating tumor cells. In this review, we impart on the use of aptamers in designing highly sensitive nanobiosensors, elaborate on the microfabrication of various microfluidic-based analytical systems, and articulate the recent advances in OC markers diagnosis using aptasensors. (C) 2021 Elsevier B.V. All rights reserved.

引用

页数：9

共 82 条

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