Bone microarchitectural analysis using ultra-high-resolution CT in tiger vertebra and human tibia

被引：10

作者：

Inai, Ryota ^{[1
]}

Nakahara, Ryuichi ^{[2
]}

Morimitsu, Yusuke ^{[3
]}

Akagi, Noriaki ^{[3
]}

Marukawa, Youhei ^{[1
]}

Matsushita, Toshi ^{[3
]}

Tanaka, Takashi ^{[1
]}

Tada, Akihiro ^{[1
]}

Hiraki, Takao ^{[1
]}

Nasu, Yoshihisa ^{[4
]}

Nishida, Keiichiro ^{[5
]}

Ozaki, Toshifumi ^{[5
]}

Kanazawa, Susumu ^{[1
]}

机构：

[1] Okayama Univ, Dept Radiol, Med Sch, Kita Ku, 2-5-1 Shikatacho, Okayama 7008558, Japan

[2] Okayama Univ, Med Sch, Intelligent Orthopaed Syst Dev, Kita Ku, 2-5-1 Shikatacho, Okayama 7008558, Japan

[3] Okayama Univ Hosp, Med Support Dept, Devis Radiol, Kita Ku, 2-5-1 Shikatacho, Okayama 7008558, Japan

[4] Okayama Univ, Med Sch, Med Mat Musculoskeletal Reconstruct, Kita Ku, 2-5-1 Shikatacho, Okayama 7008558, Japan

[5] Okayama Univ, Med Sch, Orthopaed Surg, Kita Ku, 2-5-1 Shikatacho, Okayama 7008558, Japan

来源：

EUROPEAN RADIOLOGY EXPERIMENTAL | 2020年 / 4卷 / 01期

关键词：

Osteoporosis; Bone density; Tomography (x-ray computed); X-ray microtomography; COMPUTED-TOMOGRAPHY; HR-PQCT; FRACTURE; MDCT;

D O I：

10.1186/s41747-019-0135-0

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

Background To reveal trends in bone microarchitectural parameters with increasing spatial resolution on ultra-high-resolution computed tomography (UHRCT) in vivo and to compare its performance with that of conventional-resolution CT (CRCT) and micro-CT ex vivo. Methods We retrospectively assessed 5 tiger vertebrae ex vivo and 16 human tibiae in vivo. Seven-pattern and four-pattern resolution imaging were performed on tiger vertebra using CRCT, UHRCT, and micro-CT, and on human tibiae using UHRCT. We measured six microarchitectural parameters: volumetric bone mineral density (vBMD), trabecular bone volume fraction (bone volume/total volume, BV/TV), trabecular thickness (Tb.Th), trabecular number (Tb.N), trabecular separation (Tb.Sp), and connectivity density (ConnD). Comparisons between different imaging resolutions were performed using Tukey or Dunnett T3 test. Results The vBMD, BV/TV, Tb.N, and ConnD parameters showed an increasing trend, while Tb.Sp showed a decreasing trend both ex vivo and in vivo. Ex vivo, UHRCT at the two highest resolutions (1024- and 2048-matrix imaging with 0.25-mm slice thickness) and CRCT showed significant differences (p <= 0.047) in vBMD (51.4 mg/cm(3) and 63.5 mg/cm(3)versus 20.8 mg/cm(3)), BV/TV (26.5% and 29.5% versus 13.8 %), Tb.N (1.3 l/mm and 1.48 l/mm versus 0.47 l/mm), and ConnD (0.52 l/mm(3) and 0.74 l/mm(3)versus 0.02 l/mm(3), respectively). In vivo, the 512- and 1024-matrix imaging with 0.25-mm slice thickness showed significant differences in Tb.N (0.38 l/mm versus 0.67 l/mm, respectively) and ConnD (0.06 l/mm(3)versus 0.22 l/mm(3), respectively). Conclusions We observed characteristic trends in microarchitectural parameters and demonstrated the potential utility of applying UHRCT for microarchitectural analysis.

引用

页数：11

共 20 条

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