The neuronal cytoskeleton in acute brain injury

被引:0
作者
Fitzpatrick, MO
Dewar, D
Teasdale, GM
Graham, DI
机构
[1] So Gen Hosp, Inst Neurol Sci, Dept Neurosurg, Glasgow G51 4TF, Lanark, Scotland
[2] So Gen Hosp, Inst Neurol Sci, Dept Neuropathol, Glasgow G51 4TF, Lanark, Scotland
[3] Univ Glasgow, Wellcome Surg Inst, Glasgow, Lanark, Scotland
关键词
cytoskeleton; head injury; microtubule; neurofilament;
D O I
暂无
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
The microtubules, neurofilaments and microfilaments of the neuronal cytoskeleton are essential for the normal functioning of the neurone. Recent studies have shown that disruption of the cytoskeleton may represent a final pathway in many types of neuronal cell injury with both the somato-dendritic and axonal cytoskeleton being affected. This review discusses the current evidence on the role of the neuronal cytoskeleton in the pathogenesis of traumatic brain damage.
引用
收藏
页码:313 / 317
页数:5
相关论文
共 38 条
[1]   DIFFUSE AXONAL INJURY IN NONMISSILE HEAD-INJURY [J].
ADAMS, JH ;
GRAHAM, DI ;
GENNARELLI, TA ;
MAXWELL, WL .
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, 1991, 54 (06) :481-483
[2]  
[Anonymous], GREENFIELDS NEUROPAT
[3]   EARLY IMMUNOHISTOCHEMICAL CHANGES OF MICROTUBULE-BASED MOTOR PROTEINS IN GERBIL HIPPOCAMPUS AFTER TRANSIENT ISCHEMIA [J].
AOKI, M ;
ABE, K ;
YOSHIDA, T ;
HATTORI, A ;
KOGURE, K ;
ITOYAMA, Y .
BRAIN RESEARCH, 1995, 669 (02) :189-196
[4]   SELECTIVE NEURONAL VULNERABILITY FOLLOWING TRANSIENT CEREBRAL-ISCHEMIA IN THE GERBIL - DISTRIBUTION AND TIME COURSE [J].
ARAKI, T ;
KATO, H ;
KOGURE, K .
ACTA NEUROLOGICA SCANDINAVICA, 1989, 80 (06) :548-553
[5]  
BRADY ST, 1992, NEUROREGENERATION, P7
[6]   ULTRASTRUCTURAL STUDIES OF DIFFUSE AXONAL INJURY IN HUMANS [J].
CHRISTMAN, CW ;
GRADY, MS ;
WALKER, SA ;
HOLLOWAY, KL ;
POVLISHOCK, JT .
JOURNAL OF NEUROTRAUMA, 1994, 11 (02) :173-186
[7]   TAU-PROTEIN IS ALTERED BY FOCAL CEREBRAL-ISCHEMIA IN THE RAT - AN IMMUNOHISTOCHEMICAL AND IMMUNOBLOTTING STUDY [J].
DEWAR, D ;
DAWSON, D .
BRAIN RESEARCH, 1995, 684 (01) :70-78
[8]   ALZ-50 AND UBIQUITIN IMMUNOREACTIVITY IS INDUCED BY PERMANENT FOCAL CEREBRAL-ISCHEMIA IN THE CAT [J].
DEWAR, D ;
GRAHAM, DI ;
TEASDALE, GM ;
MCCULLOCH, J .
ACTA NEUROPATHOLOGICA, 1993, 86 (06) :623-629
[9]   Changes of cytoskeletal protein immunostaining in myelinated fibre tracts after focal cerebral ischaemia in the rat [J].
Dewar, D ;
Dawson, DA .
ACTA NEUROPATHOLOGICA, 1997, 93 (01) :71-77
[10]   AXONAL DAMAGE IN SEVERE TRAUMATIC BRAIN INJURY - AN EXPERIMENTAL-STUDY IN CAT [J].
ERB, DE ;
POVLISHOCK, JT .
ACTA NEUROPATHOLOGICA, 1988, 76 (04) :347-358