The possible role of glutathione-S-transferase activity in diabetic nephropathy

被引：22

作者：

Tesauro, M. ^{[1
]}

Nistico, S. ^{[2
]}

Noce, A. ^{[1
]}

Tarantino, A. ^{[1
]}

Marrone, G. ^{[1
]}

Costa, A. ^{[3
]}

Rovella, V. ^{[1
]}

Di Cola, G. ^{[1
]}

Campia, U. ^{[4
]}

Lauro, D. ^{[5
]}

Cardillo, C. ^{[6
]}

Di Daniele, N. ^{[1
]}

机构：

[1] Univ Roma Tor Vergata, Div Nephrol & Hypertens, Dept Syst Med, Rome, Italy

[2] Univ Catanzaro Magna Graecia, Dept Hlth Sci, Catanzaro, Italy

[3] Campus Biomed Univ Rome, Ctr Integrated Res, Rome, Italy

[4] MedStar Cardiovasc Res Network Washington, Washington, DC USA

[5] Univ Roma Tor Vergata, Endocrinol Unit, Rome, Italy

[6] Catholic Univ, Internal Med, Rome, Italy

来源：

INTERNATIONAL JOURNAL OF IMMUNOPATHOLOGY AND PHARMACOLOGY | 2015年 / 28卷 / 01期

关键词：

biomarkers; diabetic nephropathy; glutathione-S-transferase; oxidative stress; TYPE-2; MICROALBUMINURIA; POLYMORPHISMS; EVOLUTION; MELLITUS; VALUES; GSTM1; T1;

D O I：

10.1177/0394632015572564

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The most common cause of end stage renal disease is diabetic nephropathy. An early diagnosis may allow an intervention to slow down disease progression. Recently, it has been hypothesized that glutathione-S-transferase (GST) activity may be a marker of severity of chronic kidney disease. In particular, a lower GST activity is present in healthy subjects compared to patients with nephropathy. In the present review we illustrate the scientific evidence underlying the possible role of GST activity in the development of diabetic nephropathy and we analyze its usefulness as a possible early biomarker of this diabetic complication.

引用

页码：129 / 133

页数：5

共 29 条

[1] Variations in erythrocyte antioxidant levels and lipid peroxidation status and in serum lipid profile parameters in relation to blood haemoglobin A1c values in individuals with type 2 diabetes mellitus
Annadurai, Thangaraj
Vasanthakumar, Azhagarsamy
Geraldine, Pitchairaj
Thomas, Philip A.
[J]. DIABETES RESEARCH AND CLINICAL PRACTICE, 2014, 105 (01) : 58 - 69
[2] Structure, catalytic mechanism, and evolution of the glutathione transferases
Armstrong, RN
[J]. CHEMICAL RESEARCH IN TOXICOLOGY, 1997, 10 (01) : 2 - 18
[3] Glutathione-s-transferase M1 and T1 polymorphisms and associations with type 1 diabetes age-at-onset
Bekris, LM
Shephard, C
Peterson, M
Hoehna, J
Yserloo, BV
Rutledge, E
Farin, F
Kavanagh, TJ
Lernmark, A
[J]. AUTOIMMUNITY, 2005, 38 (08) : 567 - 575
[4] Association of glutathione S-transferase (GSTM1, T1 and P1) gene polymorphisms with type 2 diabetes mellitus in north Indian population
Bid, H. K.
Konwar, R.
Saxena, M.
Chaudhari, P.
Agrawal, C. G.
Banerjee, M.
[J]. JOURNAL OF POSTGRADUATE MEDICINE, 2010, 56 (03) : 176 - 181
[5] GLUTATHIONE-S-TRANSFERASE OF HUMAN RED-BLOOD-CELLS - ASSAY, VALUES IN NORMAL SUBJECTS AND IN 2 PATHOLOGICAL CIRCUMSTANCES - HYPERBILIRUBINEMIA AND IMPAIRED RENAL-FUNCTION
CARMAGNOL, F
SINET, PM
RAPIN, J
JEROME, H
[J]. CLINICA CHIMICA ACTA, 1981, 117 (02) : 209 - 217
[6] Defective intracellular antioxidant enzyme production in type 1 diabetic patients with nephropathy
Ceriello, A
Morocutti, A
Mercuri, F
Quagliaro, L
Moro, M
Damante, G
Viberti, GC
[J]. DIABETES, 2000, 49 (12) : 2170 - 2177
[7] New topical treatments for psoriasis
Chiricozzi, Andrea
Pitocco, Rossella
Saraceno, Rosita
Nistico, Steven Paul
Giunta, Alessandro
Chimenti, Sergio
[J]. EXPERT OPINION ON PHARMACOTHERAPY, 2014, 15 (04) : 461 - 470
[8] Choudhary Nikhil, 2008, Iran J Kidney Dis, V2, P72
[9] Datta SK, 2010, INDIAN J BIOCHEM BIO, V47, P100
[10] Long-term Renal Outcomes of Patients With Type 1 Diabetes Mellitus and Microalbuminuria An Analysis of the Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications Cohort
de Boer, Ian H.
Rue, Tessa C.
Cleary, Patricia A.
Lachin, John M.
Molitch, Mark E.
Steffes, Michael W.
Sun, Wanjie
Zinman, Bernard
Brunzell, John D.
[J]. ARCHIVES OF INTERNAL MEDICINE, 2011, 171 (05) : 412 - 420

← 1 2 3 →