RECURRENT HAEMOPHAGOCYTIC SYNDROME IN AN HIV-INFECTED PATIENT

被引：6

作者：

Ramon, I. ^{[1
]}

Libert, M. ^{[1
]}

Guillaume, M. P. ^{[1
]}

Corazza, F. ^{[2
]}

Karmali, R. ^{[1
]}

机构：

[1] Univ Libre Bruxelles, CHU Brugmann, Serv Med Interne, Brussels, Belgium

[2] Univ Libre Bruxelles, CHU Brugmann, Hematol Lab, Brussels, Belgium

来源：

ACTA CLINICA BELGICA | 2010年 / 65卷 / 04期

关键词：

Recurrent haemophagocytic syndrome; HIV infection; human herpesvirus 8; clostridial infection;

D O I：

10.1179/acb.2010.059

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

We describe a case of recurrent haemophagocytic syndrome (HS) in an HIV-infected patient. The first episode was associated with active human herpesvirus 8 infection and progressive Kaposi's sarcoma which was successfully treated with splenectomy, foscarnet and chemotherapy. The second episode was triggered by a Clostridium difficile colitis and resolved completely after treatment with metronidazole only. Recurrent HS has rarely been described in adult patients out of the setting of relapsing malignancy or autoimmune disease. The chronic immune dysregulation and suppression due to HIV-infection may predispose our patient to development of associated HS. Prognosis of HS remains poor, especially in HIV-infected patients. Rapidly unmasking the causative factor and timely instauration of adequate treatment are critical and may improve outcome.

引用

页码：276 / 278

页数：3

共 7 条

[1] Hemophagocytic syndrome associated with clostridial infection in a pancreatic carcinoma patient [J].

Chinen, K ;

Ohkura, Y ;

Matsubara, O ;

Tsuchiya, E .

PATHOLOGY RESEARCH AND PRACTICE, 2004, 200 (03) :241-245

[2]

Emmenegger U, 2005, SWISS MED WKLY, V135, P299

[3] Hemophagocytic syndromes and infection [J].

Fisman, DN .

EMERGING INFECTIOUS DISEASES, 2000, 6 (06) :601-608

[4] HLH-2004: Diagnostic and therapeutic guidelines for hemophagocytic lymphohistiocytosis [J].

Henter, Jan-Inge ;

Horne, AnnaCarin ;

Arico, Maurizio ;

Egeler, R. Maarten ;

Filipovich, Alexandra H. ;

Imashuku, Shinsaku ;

Ladisch, Stephan ;

McClain, Ken ;

Webb, David ;

Winiarski, Jacek ;

Janka, Gritta .

PEDIATRIC BLOOD & CANCER, 2007, 48 (02) :124-131

[5] Hemophagocytic syndrome [J].

Karras, A ;

Hermine, O .

REVUE DE MEDECINE INTERNE, 2002, 23 (09) :768-778

[6]

Low P, 1998, Eur J Med Res, V3, P461

[7] Severe pancytopenia and hemophagocytosis after HHV-8 primary infection in a renal transplant patient successfully treated with foscarnet [J].

Luppi, M ;

Barozzi, P ;

Rasini, V ;

Riva, G ;

Re, A ;

Rossi, G ;

Setti, G ;

Sandrini, S ;

Facchetti, F ;

Torelli, G .

TRANSPLANTATION, 2002, 74 (01) :131-133

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