Enantioselective Total Synthesis of Sacubitril

被引：2

作者：

Kaur, Amanpreet ^{[1
]}

Gehlawat, Anju ^{[1
]}

Prakash, Ranjana ^{[1
]}

Pandey, Satyendra Kumar ^{[1
,2
]}

机构：

[1] Thapar Inst Engn & Technol, Sch Chem & Biochem, Patiala 147001, Punjab, India

[2] Banaras Hindu Univ, Inst Sci, Dept Chem, Varanasi 221005, Uttar Pradesh, India

来源：

CHEMISTRYSELECT | 2021年 / 6卷 / 33期

关键词：

Asymmetric synthesis; Evans methylation; Heck reaction; regioselective; Sharpless asymmetric dihydroxylation; ASYMMETRIC-SYNTHESIS; HECK REACTION; CORE;

D O I：

10.1002/slct.202102506

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

An efficient enantioselective approach of Sacubitril 1 (a NEP inhibitor) which is used as a combination drug with Valsartan to treat heart failure, is described. The synthesis features the Evan's asymmetric alkylation, Sharpless asymmetric diydroxylation (AD) and Heck coupling reactions as key steps.

引用

页码：8928 / 8930

页数：3

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