Enantioselective Total Synthesis of Sacubitril

被引:1
作者
Kaur, Amanpreet [1 ]
Gehlawat, Anju [1 ]
Prakash, Ranjana [1 ]
Pandey, Satyendra Kumar [1 ,2 ]
机构
[1] Thapar Inst Engn & Technol, Sch Chem & Biochem, Patiala 147001, Punjab, India
[2] Banaras Hindu Univ, Inst Sci, Dept Chem, Varanasi 221005, Uttar Pradesh, India
来源
CHEMISTRYSELECT | 2021年 / 6卷 / 33期
关键词
Asymmetric synthesis; Evans methylation; Heck reaction; regioselective; Sharpless asymmetric dihydroxylation; ASYMMETRIC-SYNTHESIS; HECK REACTION; CORE;
D O I
10.1002/slct.202102506
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
An efficient enantioselective approach of Sacubitril 1 (a NEP inhibitor) which is used as a combination drug with Valsartan to treat heart failure, is described. The synthesis features the Evan's asymmetric alkylation, Sharpless asymmetric diydroxylation (AD) and Heck coupling reactions as key steps.
引用
收藏
页码:8928 / 8930
页数:3
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