Association between the cyclooxygenase-2 rs5275T>C polymorphism and lung cancer susceptibility: a meta-analysis involving 11,682 subjects

被引：0
作者：
Ding, Hao [1 ]
Wang, Yafeng [3 ]
Jiang, Heping [4 ]
Zhang, Sheng [5 ]
Liu, Chao [2 ]
Tang, Weifeng [2 ]
机构：
[1] Jiangsu Univ, Affiliated Peoples Hosp, Dept Resp Dis, Zhenjiang 212000, Jiangsu, Peoples R China
[2] Jiangsu Univ, Affiliated Peoples Hosp, Dept Cardiothorac Surg, Zhenjiang 212000, Jiangsu, Peoples R China
[3] Peoples Hosp Xishuangbanna Dai Autonomous Prefect, Dept Cardiol, Jinghong, Yunnan Province, Peoples R China
[4] Jiangsu Univ, Dept Emergency, Affiliated Jintan Peoples Hosp, Jintan, Peoples R China
[5] Changzhou 3 Peoples Hosp, Dept Gen Surg, Changzhou, Jiangsu, Peoples R China
来源：
INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE | 2016年 / 9卷 / 03期
关键词：
Lung cancer; polymorphism; COX-2; susceptibility; meta-analysis; COMMON POLYMORPHISM; RISK; GENES; INFLAMMATION; EXPOSURE; SMOKING; DISEASE;
D O I：
暂无
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
The possible correlation of cyclooxygenase-2 (COX-2) rs5275T>C polymorphism with lung cancer risk has been widely investigated. However, the results remain controversial. To identify the relationship more precisely, we carried out a pooled analysis of ten publications involving a total of 11,682 subjects. In this study, ten publications were recruited by extensive searching PubMed and EMBASE databases up to September 14, 2015. The lung cancer risk correlated with the COX-2 rs5275T>C variants was evaluated by odds ratios (ORs) with 95% confidence intervals (95% CIs). Publication bias, heterogeneity and sensitivity analysis were also assessed. The results showed that the COX-2 rs5275T>C variants were not associated with overall lung cancer susceptibility. In a stratified analysis by histology, the relationship between COX-2 rs5275T>C polymorphism and decreased lung cancer susceptibility was significant in mixed histology lung cancer. In summary, our study demonstrated that the COX-2 rs5275T>C polymorphism may be a lung cancer susceptibility factor.
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收藏
页码：5584 / 5592
页数：9
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