Splenic infarction associated with transient anti-prothrombin antibodies is a rare manifestation of acute Mycoplasma pneumoniae infection

被引：21

作者：

Pachet, A. ^{[1
]}

Dumestre-Perard, C. ^{[2
,3
]}

Moine, M. ^{[1
]}

Marlu, R. ^{[4
]}

Rubio, A. ^{[5
,6
,7
]}

Bost-Bru, C. ^{[8
]}

机构：

[1] CHU Grenoble Alpes, Hop Couple Enfant, Serv Reanimat & Surveillance Continue Pediat, F-38000 Grenoble, France

[2] CHU Grenoble Alpes, Lab Immunol, F-38000 Grenoble, France

[3] Univ Grenoble Alpes, CNRS, BNI TIMC, IMAG,UMR5525, F-38000 Grenoble, France

[4] CHU Grenoble Alpes, Lab Hemostase, F-38000 Grenoble, France

[5] CHU Grenoble Alpes, Hop Couple Enfants, Serv Pediat Specialite, F-38000 Grenoble, France

[6] Univ Grenoble Alpes, F-38000 Grenoble, France

[7] CHU Grenoble Alpes, Unite INSERM CIC1406, Antenne Pediat CIC, F-38000 Grenoble, France

[8] CHU Grenoble Alpes, Hop Couple Enfant, Serv Pediat Gen, F-38000 Grenoble, France

来源：

ARCHIVES DE PEDIATRIE | 2019年 / 26卷 / 08期

关键词：

Mycoplasma pneumoniae; Antiphospholipid antibodies; anti-prothrombin antibodies; Splenic infarction; Thrombosis; ANTIPHOSPHOLIPID SYNDROME; PREVALENCE;

D O I：

10.1016/j.arcped.2019.10.001

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

We report the first paediatric case of splenic infarction following acute Mycoplasma pneumoniae infection with induction of anti-prothrombin (aPT) antibodies. A 12-year-old boy was admitted to the paediatric emergency department for a left pleuropneumonia and a splenic infarction. aPT antibodies were transitorily detected. The patient recovered fully after antibiotic therapy and a 3-month course of anticoagulation treatment. Antiphospholipid (aPL) antibodies induced by acute infections have already been reported but cases of clinically relevant thrombosis remain rare. The pathogenicity of aPT antibodies is discussed here. We hypothesize that these antibodies were involved in this symptomatic hypercoagulable state. (C) 2019 Published by Elsevier Masson SAS on behalf of French Society of Pediatrics.

引用

页码：483 / 486

页数：4

共 14 条

[1] Systematic review of case reports of antiphospholipid syndrome following infection [J].