A novel day blindness in sheep: Epidemiological, behavioural, electrophysiological and histopathological studies

被引：33

作者：

Shamir, Merav H. ^{[2
]}

Ofri, Ron ^{[2
]}

Bor, Amir ^{[3
]}

Brenner, Ori ^{[4
]}

Reicher, Shay ^{[1
,5
]}

Obolensky, Alexey ^{[6
]}

Averbukh, Edward ^{[6
]}

Banin, Eyal ^{[6
]}

Gootwine, Elisha ^{[1
]}

机构：

[1] Agr Res Org, Volcani Ctr, IL-50250 Bet Dagan, Israel

[2] Hebrew Univ Jerusalem, Koret Sch Vet Med, IL-76100 Rehovot, Israel

[3] Bor Clin, IL-67329 Tel Aviv, Israel

[4] Weizmann Inst Sci, IL-76100 Rehovot, Israel

[5] Hebrew Univ Jerusalem, Robert H Smith Fac Agr Food & Environm, IL-76100 Rehovot, Israel

[6] Hadassah Hebrew Univ, Med Ctr, Dept Ophthalmol, IL-91120 Jerusalem, Israel

来源：

VETERINARY JOURNAL | 2010年 / 185卷 / 02期

关键词：

Awassi sheep; Day blindness; Achromatopsia; CONE; VISION; ACHROMATOPSIA; PHENOTYPES; MUTATIONS; AWASSI; MODEL;

D O I：

10.1016/j.tvjl.2009.05.029

中图分类号：

S85 [动物医学（兽医学）];

学科分类号：

0906 ;

摘要：

Four genetically related Improved Awassi sheep flocks had sporadic births of lambs with congenital visual impairments that differed from other known forms of sheep blindness. Pedigree analysis suggested an autosomal recessive mode of inheritance. Behavioural studies of 4-month old affected lambs showed that their day vision (but not night vision) was impaired. Electrophysiological results at this age demonstrated diminished function of cones but not rods. Histopathological and immunohistochemical evaluation of affected retinas from 5-month old lambs revealed both red-green and blue cones, suggesting that the behavioural day blindness and reduced cone electroretinograms reflect cone dysfunction rather than severe cone photoreceptor loss. Awassi day blindness may be a form of achromatopsia. (C) 2009 Elsevier Ltd. All rights reserved.

引用

页码：130 / 137

页数：8