The Effect of Different Doses of Intramuscular Xylazine HCl Administration on Intraocular Pressure in Rabbits

被引：1

作者：

Dogan, Elif ^{[1
]}

Yanmaz, Latif Emrah ^{[1
]}

Ersoz, Ugur ^{[1
]}

Senocak, Mumin Gokhan ^{[1
]}

Okumus, Zafer ^{[1
]}

机构：

[1] Ataturk Univ, Fac Vet, Dept Surg, TR-25240 Erzurum, Turkey

来源：

KAFKAS UNIVERSITESI VETERINER FAKULTESI DERGISI | 2016年 / 22卷 / 05期

关键词：

Intraocular pressure; New Zealand White rabbit; Xylazine HCl; ANESTHESIA; KETAMINE;

D O I：

10.9775/kvfd.2016.15222

中图分类号：

S85 [动物医学（兽医学）];

学科分类号：

0906 ;

摘要：

This study was aimed to determine the effects of intramuscular Xylazine HCl administration on intraocular pressure (IOP) in rabbits at 5 mg/kg (XYL-5) and 10 mg/kg (XYL-10) doses. IOP measurements were recorded at baseline (T-(1)), and at 5 (T-5), 10 (T-10), 15 (T-15), 20 (T-20), 30 (T-30), 45 (T-45) and 60 (T-60) minutes following Xylazine HCl administration. IOP values were significantly decreased at T-15 in group XYL-5 (8.37 +/- 1.45 mm Hg) and at T-5 in group XYL-10 (8.00 +/- 1.13 mm Hg). In conclusion, intramuscular Xylazine HCl significantly reduced IOP in rabbits at the latest after 15 minutes of administration, regardless of the doses used in this study.

引用

页码：801 / 803

页数：3

共 15 条

[1] Update on the role of alpha-agonists in glaucoma management [J].

Arthur, Stella ;

Cantor, Louis B. .

EXPERIMENTAL EYE RESEARCH, 2011, 93 (03) :271-283

[2] The Effect of Vasopressin on Ciliary Blood Flow and Aqueous Flow [J].

Bogner, Barbara ;

Runge, Christian ;

Strohmaier, Clemens ;

Trost, Andrea ;

Tockner, Birgit ;

Kiel, Jeffrey W. ;

Schroedl, Falk ;

Reitsamer, Herbert A. .

INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 2014, 55 (01) :396-403

[3]

BORKOWSKI GL, 1990, LAB ANIM SCI, V40, P270

[4]

Burke J A, 1986, J Ocul Pharmacol, V2, P9, DOI 10.1089/jop.1986.2.9

[5] Preparation of animals for research - Issues to consider for rodents and rabbits [J].

Conour, Laura A. ;

Murray, Kathleen A. ;

Brown, Marilyn J. .

ILAR JOURNAL, 2006, 47 (04) :283-293

[6]

Hazra S, 2011, SCAND J LAB ANIM SCI, V38, P81

[7]

Holve DL, 2013, J AM ASSOC LAB ANIM, V52, P488

[8] Effects of medetomidine and xylazine on intraocular pressure and pupil size in healthy Beagle dogs [J].

Kanda, Teppei ;

Iguchi, Ayano ;

Yoshioka, Chieko ;

Nomura, Haruka ;

Higashi, Kanako ;

Kaya, Minami ;

Yamamoto, Rie ;

Kuramoto, Tomoko ;

Furukawa, Toshinori .

VETERINARY ANAESTHESIA AND ANALGESIA, 2015, 42 (06) :623-628

[9] Rabbit and rodent ophthalmology [J].

Kern, TJ .

SEMINARS IN AVIAN AND EXOTIC PET MEDICINE, 1997, 6 (03) :138-145

[10] Immobilization stress induces elevation of intraocular pressure in rabbits [J].

Miyazaki, Y ;

Matsuo, T ;

Kurabayashi, Y .

OPHTHALMIC RESEARCH, 2000, 32 (06) :270-277

← 1 2 →