Comparison of the early effects of vonoprazan, lansoprazole and famotidine on intragastric pH: a three-way crossover study

被引：15

作者：

Ohkuma, Kanji ^{[1
]}

Iida, Hiroshi ^{[2
]}

Inoh, Yumi ^{[1
]}

Kanoshima, Kenji ^{[1
]}

Ohkubo, Hidenori ^{[1
]}

Nonaka, Takashi ^{[1
]}

Fujita, Koji ^{[1
]}

Kusakabe, Akihiko ^{[3
]}

Inamori, Masahiko ^{[2
]}

Nakajima, Atsushi ^{[1
]}

机构：

[1] Yokohama City Univ, Sch Med, Dept Gastroenterol & Hepatol, Kanazawa Ku, 3-9 Fukuura, Yokohama, Kanagawa 2360004, Japan

[2] Yokohama City Univ, Sch Med, Dept Med Educ, Kanazawa Ku, 3-9 Fukuura, Yokohama, Kanagawa 2360004, Japan

[3] Yokohama City Univ, Sch Med, Dept Gen Med, Kanazawa Ku, 3-9 Fukuura, Yokohama, Kanagawa 2360004, Japan

来源：

JOURNAL OF CLINICAL BIOCHEMISTRY AND NUTRITION | 2018年 / 63卷 / 01期

关键词：

intragastric acidity; vonoprazan; lansoprazole; famotidine; GASTROESOPHAGEAL-REFLUX DISEASE; HELICOBACTER-PYLORI INFECTION; PROTON PUMP INHIBITORS; COMPETITIVE ACID BLOCKER; HEALTHY MALE-SUBJECTS; QUALITY-OF-LIFE; ON-DEMAND USE; TAK-438; VONOPRAZAN; GASTRIC-ACID; OMEPRAZOLE;

D O I：

10.3164/jcbn.17-128

中图分类号：

R15 [营养卫生、食品卫生]; TS201 [基础科学];

学科分类号：

100403 ;

摘要：

To promote symptom relief from acid-related diseases, a medicine with a rapid-onset effect is ideal. The aim of this study was to investigate the early inhibitory effect on gastric acid secretion after a single oral administration of vonoprazan, which represents a new class of proton pump inhibitors, and to compare this effect with those of lansoprazole and famotidine. Ten Helicobacter pylori (HP)-negative male subjects participated in this randomized, three-way crossover study. A single oral administration of vonoprazan (20 mg), lansoprazole (30 mg) or famotidine (20 mg) was performed, and the intragastric pH was continuously monitored for 6 h. Each drug was administered at least seven days apart. The average intragastric pH during the 6-h period after the administration of famotidine was higher than that after the administration of lansoprazole (median: 4.45 vs 2.65; p = 0.0284). A similar result was observed for vonoprazan and lansoprazole (median: 4.30 vs 2.65; p = 0.0322). In conclusions, oral administration of vonoprazan and famotidine in HP-negative healthy male subjects caused the intragastric pH to rise more quickly than did lansoprazole.

引用

页码：80 / 83

页数：4

共 39 条

[21] EFFECT OF SINGLE AND REPEATED INTRAVENOUS DOSES OF OMEPRAZOLE ON PENTAGASTRIN STIMULATED GASTRIC-ACID SECRETION AND PHARMACOKINETICS IN MAN [J].