Recent advances in the medical therapy of Crohn's disease in childhood

被引:5
作者
Bremner, A. R.
Beattie, R. M.
机构
[1] Southampton Gen Hosp, Paediat Med Unit, Southampton SO16 6YD, Hants, England
[2] Bristol Royal Hosp Children, Dept Paediat Gastroenterol, Bristol BS2 8BJ, Avon, England
关键词
biological therapy; child; corticosteroid; Crohn's disease; enteral nutrition; immunosuppression; inflammatory bowel disease; probiotics; therapy;
D O I
10.1517/14656566.8.15.2553
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Crohn's disease (CrD) is characterised by an ongoing inflammatory response in the gut, in the absence of an obvious trigger. The treatment of CrD in children, during relapse and remission, requires special consideration of growth and development. This review addresses the use of present medical management strategies, including enteral nutrition, corticosteroids, immunosuppression and anti-TNF-alpha therapies. Anti-inf lammatory IL-11 and leukocyte adhesion inhibitors have shown only moderate clinical efficacy in adults. Emerging treatments directed against the inflammatory cascade under investigation include inhibitors of IL-6 and -12, IFN-gamma and MAPKs. Probiotics and colony stimulating factors aim to stimulate the innate immune system. Research data from clinical trials are reviewed and summarised in respect of their potential within paecliatric practice.
引用
收藏
页码:2553 / 2568
页数:16
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