Electrocardiographic findings in sickle cell cardiovascular autonomic neuropathy

被引:4
作者
Oguanobi, N. I. [1 ,2 ]
Ejim, E. C. [2 ]
Anisiuba, B. C. [2 ]
Onwubere, B. J. C. [2 ]
Ike, S. O. [2 ]
Ibegbulam, O. G. [3 ]
机构
[1] Fed Med Ctr, Dept Med, Asaba, Delta State, Nigeria
[2] Univ Nigeria Teaching Hosp, Dept Med, Enugu, Nigeria
[3] Univ Nigeria Teaching Hosp, Dept Haematol, Enugu, Nigeria
关键词
Electrocardiographic findings; Cardiovascular autonomic neuropathy; Sickle cell anaemia; HEART-RATE-VARIABILITY; LOW-FREQUENCY POWER; SUDDEN-DEATH; MYOCARDIAL-INFARCTION; PROGNOSTIC VALUE; Q-WAVES; DISPERSION; PREDICTOR; REFLEXES; FAILURE;
D O I
10.1007/s10286-011-0156-0
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
There is a lack of data on the relationship between cardiovascular autonomic neuropathy (CAN) and electrocardiographic parameters in sickle cell anaemia. The purpose of the study was to compare the electrocardiographic findings in adult sickle cell anaemia patients with CAN with those of patients without this complication. A cross sectional study was done using 62 consecutively recruited sickle cell anaemia patients who met the inclusion criteria for the study. Cardiovascular autonomic dysfunction was determined based on abnormal values in at least two of five non-invasive tests: Valsalva manoeuver, heart rate variation during deep breathing, heart rate response to standing, blood pressure response to sustained hand grip, and blood pressure response to standing. The subjects were subsequently evaluated with electrocardiography. Sickle cell anaemia patients with CAN had statistically significantly increased P-wave duration ( < 0.001), PR-interval ( < 0.05) and QTc dispersion ( < 0.05) compared with patients without CAN. Significantly increased frequencies of Q waves and first degree atrio-ventricular block were found in patients with CAN than in those without CAN ( = 0.026, = 0.014, respectively). Significant correlations were noted between the severity of CAN [number of abnormal autonomic function tests (AFT)] and (1) P-wave duration ( = 0.008), (2) PR- interval ( = 0.013). Significant association was found between the number of abnormal AFT and (1) presence of Q-waves, and (2) degree of anaemia (haematocrit class). Electrocardiographic features consistent with atrio-ventricular and ventricular repolarization abnormalities are associated with CAN in sickle cell anaemia. Further studies are required to evaluate the prognostic implications of these findings in sickle cell patients with cardiovascular autonomic dysfunction.
引用
收藏
页码:137 / 145
页数:9
相关论文
共 50 条
[41]   Diagnosis, Staging, and Associated Conditions of Cardiovascular Autonomic Neuropathy in Libyan Patients with Diabetes [J].
Elmiladi, Samia A. ;
Elgdhafi, Elham O. ;
Shukri, Ahmed A. .
IBNOSINA JOURNAL OF MEDICINE AND BIOMEDICAL SCIENCES, 2021, 13 (04) :215-221
[42]   Study of Cardiovascular Autonomic Neuropathy in Symptomatic and Asymptomatic Type II Diabetic Patients [J].
Garikapati, Kranthi Kumar ;
Tripathi, Yogesh ;
Garg, Rinku ;
Garg, Bindu .
PAKISTAN JOURNAL OF MEDICAL & HEALTH SCIENCES, 2021, 15 (03) :1069-1073
[43]   Diabetic Cardiovascular Autonomic Neuropathy, the Handgrip Test and Ambulatory Blood Pressure Monitoring Parameters: Are There Any Diagnostic Implications? [J].
Kempler, Miklos ;
Hajdu, Noemi ;
Putz, Zsuzsanna ;
Istenes, Ildiko ;
Vagi, Orsolya ;
Bekeffy, Magdolna ;
Schnabel, Karolina ;
Kempler, Peter ;
Korei, Anna E. .
JOURNAL OF CLINICAL MEDICINE, 2020, 9 (10) :1-12
[44]   Cardiovascular autonomic neuropathy in patients with type 2 diabetes mellitus and coronary artery disease: Diagnosis and severity assessment [J].
Beshlieva, D. D. ;
Kalashnikov, V. Yu. ;
Smirnova, O. M. .
TERAPEVTICHESKII ARKHIV, 2015, 87 (10) :11-18
[45]   Analysis of the association between glucose profiles and β-cell function for diabetic cardiovascular autonomic neuropathy in China [J].
Fang, Ping ;
Dong, Jingcheng ;
Zeng, Fangfang ;
Tang, Zihui .
JOURNAL OF DIABETES INVESTIGATION, 2017, 8 (03) :354-362
[46]   Cardiovascular autonomic neuropathy, autonomic symptoms and diabetic complications in 674 type 2 diabetes [J].
Chen, Hung-Ta ;
Lin, Hong-Da ;
Won, Justin G. S. ;
Lee, Chen-Hsen ;
Wu, Shiao-Chi ;
Lin, Jiun-Dian ;
Juan, Li-Ying ;
Ho, Low-Tone ;
Tang, Kam-Tsun .
DIABETES RESEARCH AND CLINICAL PRACTICE, 2008, 82 (02) :282-290
[47]   Cardiovascular autonomic neuropathy associates with nephropathy lesions in American Indians with type 2 diabetes [J].
Wheelock, Kevin M. ;
Jaiswal, Mamta ;
Martin, Catherine L. ;
Fufaa, Gudeta D. ;
Weil, E. Jennifer ;
Lemley, Kevin V. ;
Yee, Berne ;
Feldman, Eva ;
Brosius, Frank C., III ;
Knowler, William C. ;
Nelson, Robert G. ;
Pop-Busui, Rodica .
JOURNAL OF DIABETES AND ITS COMPLICATIONS, 2016, 30 (05) :873-879
[48]   Screening of Cardiovascular Autonomic Neuropathy in Patients with Diabetes by Quick and Simple Assessment of Sudomotor Function [J].
Calvet, J. H. ;
Dupin, J. ;
Deslypere, J. P. .
JOURNAL OF DIABETES & METABOLISM, 2012, 3 (04)
[49]   Cardiovascular autonomic neuropathy and incident diabetic kidney disease in patients with type 2 diabetes [J].
Jun, Ji Eun ;
Choi, Min Sun ;
Kim, Jae Hyeon .
DIABETES RESEARCH AND CLINICAL PRACTICE, 2022, 184
[50]   Disease-modifying antirheumatic drugs improve cardiovascular autonomic neuropathy in psoriatic arthritis [J].
Syngle, Ashit ;
Verma, Inderjeet ;
Krishan, Pawan ;
Syngle, Vijaita .
THERAPEUTIC ADVANCES IN MUSCULOSKELETAL DISEASE, 2016, 8 (02) :42-48