Does celiac disease occur in Afro-derived Brazilian populations?

被引：12

作者：

Almeida, Rodrigo C. ^{[2
]}

Gandolfi, Lenora ^{[2
]}

Klautau-Guimaraes, Maria de Nazare ^{[1
]}

Ferrari, Iris ^{[1
]}

Sousa, Sandra M. B. ^{[3
]}

Abe-Sandes, Kiyoko ^{[4
]}

Barbosa, Ana A. L. ^{[5
]}

Simoes, Aguinaldo L. ^{[6
]}

Pratesi, Riccardo ^{[2
]}

Oliveira, Silviene F. ^{[1
]}

机构：

[1] Univ Brasilia, Inst Ciencias Biol, Dept Genet & Morfol, Genet Lab, BR-70910900 Brasilia, DF, Brazil

[2] Univ Brasilia, Ctr Pesquisa Doenca Celiaca, Fac Med, BR-70910900 Brasilia, DF, Brazil

[3] Univ Estadual Santa Cruz, Dept Ciencias Biol, Ilheus, BA, Brazil

[4] Univ Estado Bahia, Dept Ciencias Vida, Salvador, BA, Brazil

[5] Univ Estadual Sudoeste Bahia, Dept Ciencias Biol, Jequie, BA, Brazil

[6] Univ Sao Paulo, Dept Genet, Fac Med Ribeirao Preto, Sao Paulo, Brazil

来源：

AMERICAN JOURNAL OF HUMAN BIOLOGY | 2012年 / 24卷 / 05期

关键词：

PREVALENCE;

D O I：

10.1002/ajhb.22271

中图分类号：

Q98 [人类学];

学科分类号：

030303 ;

摘要：

Background: Celiac disease is an autoimmune disorder that occurs in genetically susceptible individuals in whom the ingestion of dietary gluten induces intestinal mucosa inflammation. Previous studies suggest that celiac disease may either be very rare or underdiagnosed in African and/or African-derived population. Aim: Determine the prevalence of celiac disease in Sub-Saharan African-derived Brazilian communities using serological screening. Subjects and methods: Inhabitants from 10 African-derived communities from Northeastern of Brazil were screened for celiac disease. All sera were tested for endomysial class IgA antibody using indirect immunofluorescence. Results: No positive test for IgA-endomysial was observed in the 860 individuals tested. Conclusion: Our data suggests a low prevalence of celiac disease in African-derived Brazilian populations. Am. J. Hum. Biol., 2012. (c) 2012 Wiley Periodicals, Inc.

引用

页码：710 / 712

页数：3

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