A review of the application of nanoparticles in the diagnosis and treatment of chronic kidney disease

被引：62

作者：

Ma, Yanhong ^{[1
]}

Cai, Fanghao ^{[1
]}

Li, Yangyang ^{[2
]}

Chen, Jianghua ^{[1
]}

Han, Fei ^{[1
]}

Lin, Weiqiang ^{[1
,2
]}

机构：

[1] Zhejiang Univ, Kidney Dis Ctr, Affiliated Hosp 1, Sch Med,Inst Nephrol,Key Lab Kidney Dis Prevent &, Hangzhou 310003, Zhejiang, Peoples R China

[2] Zhejiang Univ, Inst Translat Med, Sch Med, Hangzhou 310029, Peoples R China

来源：

BIOACTIVE MATERIALS | 2020年 / 5卷 / 03期

基金：

国家重点研发计划; 中国国家自然科学基金;

关键词：

Chronic kidney disease; Nanoparticles; Diagnosis; Treatment; SENSITIVE ELECTROCHEMILUMINESCENCE IMMUNOSENSOR; SUPERPARAMAGNETIC IRON-OXIDE; GLOMERULAR-BASEMENT-MEMBRANE; SALVIANOLIC-ACID-B; ELECTROCHEMICAL IMMUNOSENSOR; SILICA NANOPARTICLES; INJURY MOLECULE-1; CURRENT PROGRESS; CONTRAST AGENTS; QUANTUM DOTS;

D O I：

10.1016/j.bioactmat.2020.05.002

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

Chronic kidney disease (CKD) poses a great burden to global public health as current therapies are generally ineffective. Early detection and effective therapy are crucial for the future prevention and progression of CKD. Nanoparticles (NPs) vary by particle size, charge, shape and the density of targeting ligands and are associated with enhancement of the pharmacokinetic properties, targetability, or the bioavailability of drugs. Thus, the emergence of NPs in medicine has provided novel solutions to the potential diagnosis and treatment of CKD. This review describes the current experimental research, clinical applications of NPs, the current challenges, and upcoming opportunities in the diagnosis and treatment of CKD.

引用

页码：732 / 743

页数：12

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