Taste masking of paracetamol by hot-melt extrusion: An in vitro and in vivo evaluation

被引：134
|
作者：
Maniruzzaman, Mohammed [1 ]
Boateng, Joshua S. [1 ]
Bonnefille, Marion [2 ]
Aranyos, Attila [2 ]
Mitchell, John C. [1 ]
Douroumis, Dennis [1 ]
机构：
[1] Univ Greenwich, Sch Sci, London SE18 6PF, Kent, England
[2] Alpha MOS, Toulouse, France
来源：
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS | 2012年 / 80卷 / 02期
关键词：
Hot-melt extrusion; Taste masking; Electronic tongue; Solubility parameter; SOLUBILITY PARAMETERS; SOLID DISPERSIONS; ELECTRONIC TONGUE; PHARMACEUTICAL APPLICATIONS; FORMULATION DEVELOPMENT; DISINTEGRATING TABLETS; RELEASE; BITTERNESS; POLYMERS; GRANULES;
D O I：
10.1016/j.ejpb.2011.10.019
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
The purpose of this study was the in vitro and in vivo evaluation of the masking efficiency of hot melt extruded paracetamol (PMOL) formulations. Extruded granules containing high PMOL loadings in Eudragit EPO (R) (EPO) or Kollidon (R) VA64 (VA64) were prepared by hot-melt extrusion (HME). The taste masking effect of the processed formulation was evaluated in vivo by a panel of six healthy human volunteers. In addition, in vitro evaluation was carried out by an Astree e-tongue equipped with seven sensors. Taste sensing technology demonstrated taste improvement for both polymers by correlating the data obtained for the placebo polymers and the pure APIs alone. The best masking effect was observed for VA64 at 30% PMOL loading. The e-tongue results were in good agreement with the in vivo evaluation. In vitro dissolution of the extruded granules showed rapid PMOL releases. (C) 2011 Elsevier B.V. All rights reserved.
引用
收藏
页码：433 / 442
页数：10
相关论文
共 50 条
  • [41] Scale-up challenges in hot-melt extrusion: Critical issues that should be considered when scaling up a hot-melt extrusion process
    Markarian, Jennifer
    Pharmaceutical Technology, 2012, 36 (04) : 88 - 92
  • [42] NMR and Thermal Studies for the Characterization of Mass Transport and Phase Separation in Paracetamol/Copovidone Hot-Melt Extrusion Formulations
    Pisa, Elena
    Hughes, Leslie P.
    Wren, Stephen A. C.
    Booth, Jonathan
    McCabe, James Francis
    Whittaker, David T. E.
    Mantle, Mick D.
    MOLECULAR PHARMACEUTICS, 2020, 17 (06) : 2021 - 2033
  • [43] Development of Ternary Amorphous Solid Dispersions Manufactured by Hot-Melt Extrusion and Spray-Drying-Comparison of In Vitro and In Vivo Performance
    Trenkenschuh, Eduard
    Blattner, Simone M.
    Hirsh, David
    Hoffmann, Ragna
    Luebbert, Christian
    Schaefer, Kerstin
    MOLECULAR PHARMACEUTICS, 2024, 21 (03) : 1309 - 1320
  • [44] Preparation and Evaluation of Clarithromycin Taste-Masking Dry Suspension Using Hot Melt Extrusion Based on Solid Dispersion Technology
    Zhang, Tianao
    Yu, Min
    Fan, Yong
    Wang, Lingyang
    Yuan, Lu
    Sun, Yong
    CHEMICAL & PHARMACEUTICAL BULLETIN, 2024, 72 (07) : 681 - 688
  • [45] Preparation of sustained release co-extrudates by hot-melt extrusion and mathematical modelling of in vitro/in vivo drug release profiles
    Quintavalle, U.
    Voinovich, D.
    Perissutti, B.
    Serdoz, E.
    Grassi, G.
    Dal Col, A.
    Grassi, M.
    EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES, 2008, 33 (03) : 282 - 293
  • [46] Formulation and Evaluation of Fenbendazole Extended-Release Extrudes Processed by Hot-Melt Extrusion
    Bezerra, Gilberto S. N.
    de Lima, Tielidy A. de M.
    Colbert, Declan M.
    Geever, Joseph
    Geever, Luke
    POLYMERS, 2022, 14 (19)
  • [47] Evaluation of Abuse-Deterrent Characteristics of Tablets Prepared via Hot-Melt Extrusion
    Xiaoming Xu
    Akhtar Siddiqui
    Charudharshini Srinivasan
    Adil Mohammad
    Ziyaur Rahman
    Maxwell Korang-Yeboah
    Xin Feng
    Mansoor Khan
    Muhammad Ashraf
    AAPS PharmSciTech, 20
  • [48] Evaluation of Abuse-Deterrent Characteristics of Tablets Prepared via Hot-Melt Extrusion
    Xu, Xiaoming
    Siddiqui, Akhtar
    Srinivasan, Charudharshini
    Mohammad, Adil
    Rahman, Ziyaur
    Korang-Yeboah, Maxwell
    Feng, Xin
    Khan, Mansoor
    Kshraf, Muhammad
    AAPS PHARMSCITECH, 2019, 20 (06)
  • [49] Towards predicting the product quality in hot-melt extrusion: Small scale extrusion
    Matic, Josip
    Alva, Carolina
    Witschnigg, Andreas
    Eder, Simone
    Reusch, Kathrin
    Paudel, Amrit
    Khinast, Johannes
    INTERNATIONAL JOURNAL OF PHARMACEUTICS-X, 2020, 2
  • [50] Development of taste masked caffeine citrate formulations utilizing hot melt extrusion technology and in vitro-in vivo evaluations
    Pimparade, Manjeet B.
    Morott, Joseph T.
    Park, Jun-Born
    Kulkarni, Vijay I.
    Majumdar, Soumyajit
    Murthy, S. N.
    Lian, Zhuoyang
    Pinto, Elanor
    Bi, Vivian
    Dung, Thomas
    Murthy, Reena
    Shivakumar, H. N.
    Vanaja, K.
    Kumar, P. C.
    Repka, Michael A.
    INTERNATIONAL JOURNAL OF PHARMACEUTICS, 2015, 487 (1-2) : 167 - 176
12345