Ex vivo repair of human donor lungs for transplantation

被引：0
作者：
Fisher, Andrew J. [1 ]
Dark, John H.
机构：
[1] Newcastle Univ, Translat & Clin Res Inst, Regenerat Med Stem Cells & Transplantat Theme, Newcastle Upon Tyne, Tyne & Wear, England
来源：
NATURE MEDICINE | 2020年 / 26卷 / 07期
关键词：
PERFUSION;
D O I：
10.1038/s41591-020-0967-4
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Injured human donor lungs deemed unsuitable for immediate transplantation may be successfully recovered by connection into the circulation of a porcine host with perfusion and ventilation ex vivo for 24 hours.
引用
收藏
页码：1015 / 1016
页数：2
相关论文
共 12 条
  • [1] Ex vivo lung perfusion in clinical lung transplantation-State of the art
    Andreasson, Anders S. I.
    Dark, John H.
    Fisher, Andrew J.
    [J]. EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY, 2014, 46 (05) : 779 - 788
  • [2] The Cellular and Physiological Basis for Lung Repair and Regeneration: Past, Present, and Future
    Basil, Maria C.
    Katzen, Jeremy
    Engler, Anna E.
    Guo, Minzhe
    Herriges, Michael J.
    Kathiriya, Jaymin J.
    Windmueller, Rebecca
    Ysasi, Alexandra B.
    Zacharias, William J.
    Chapman, Hal A.
    Kotton, Darrell N.
    Rock, Jason R.
    Snoeck, Hans-Willem
    Vunjak-Novakovic, Gordana
    Whitsett, Jeffrey A.
    Morrisey, Edward E.
    [J]. CELL STEM CELL, 2020, 26 (04) : 482 - 502
  • [3] Normothermic Ex Vivo Lung Perfusion in Clinical Lung Transplantation
    Cypel, Marcelo
    Yeung, Jonathan C.
    Liu, Mingyao
    Anraku, Masaki
    Chen, Fengshi
    Karolak, Wojtek
    Sato, Masaaki
    Laratta, Jane
    Azad, Sassan
    Madonik, Mindy
    Chow, Chung-Wai
    Chaparro, Cecilia
    Hutcheon, Michael
    Singer, Lianne G.
    Slutsky, Arthur S.
    Yasufuku, Kazuhiro
    de Perrot, Marc
    Pierre, Andrew F.
    Waddell, Thomas K.
    Keshavjee, Shaf
    [J]. NEW ENGLAND JOURNAL OF MEDICINE, 2011, 364 (15) : 1431 - 1440
  • [4] Elevated levels of interleukin-8 in donor lungs is associated with early craft failure after lung transplantation
    Fisher, AJ
    Donnelly, SC
    Hirani, N
    Haslett, C
    Strieter, RM
    Dark, JH
    Corris, PA
    [J]. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2001, 163 (01) : 259 - 265
  • [5] Enhanced pulmonary inflammation in organ donors following fatal nontraumatic brain injury
    Fisher, AJ
    Donnelly, SC
    Hirani, N
    Burdick, MD
    Strieter, RM
    Dark, JH
    Corris, PA
    [J]. LANCET, 1999, 353 (9162) : 1412 - 1413
  • [6] Normothermic machine perfusion of donor-lungs ex-vivo: promoting clinical adoption
    Gilmour, Jenny
    Griffiths, Chelsea
    Pither, Tom
    Scott, William E.
    Fisher, Andrew J.
    [J]. CURRENT OPINION IN ORGAN TRANSPLANTATION, 2020, 25 (03) : 285 - 292
  • [7] Xenogeneic cross-circulation for extracorporeal recovery of injured human lungs
    Hozain, Ahmed E.
    O'Neill, John D.
    Pinezich, Meghan R.
    Tipograf, Yuliya
    Donocoff, Rachel
    Cunningham, Katherine M.
    Tumen, Andrew
    Fung, Kenmond
    Ukita, Rei
    Simpson, Michael T.
    Reimer, Jonathan A.
    Ruiz, Edward C.
    Queen, Dawn
    Stokes, John W.
    Cardwell, Nancy L.
    Talackine, Jennifer
    Kim, Jinho
    Snoeck, Hans-Willem
    Chen, Ya-Wen
    Romanov, Alexander
    Marboe, Charles C.
    Griesemer, Adam D.
    Guenthart, Brandon A.
    Bacchetta, Matthew
    Vunjak-Novakovic, Gordana
    [J]. NATURE MEDICINE, 2020, 26 (07) : 1102 - 1113
  • [8] Multiday maintenance of extracorporeal lungs using cross-circulation with conscious swine
    Hozain, Ahmed E.
    Tipograf, Yuliya
    Pinezich, Meghan R.
    Cunningham, Katherine M.
    Donocoff, Rachel
    Queen, Dawn
    Fung, Kenmond
    Marboe, Charles C.
    Guenthart, Brandon A.
    O'Neill, John D.
    Vunjak-Novakovic, Gordana
    Bacchetta, Matthew
    [J]. JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY, 2020, 159 (04) : 1640 - 1652
  • [9] Lung xenotransplantation: a review
    Laird, Chris
    Burdorf, Lars
    Pierson, Richard N., III
    [J]. CURRENT OPINION IN ORGAN TRANSPLANTATION, 2016, 21 (03) : 272 - 278
  • [10] Prediction of transplant outcome after 24-hour ex vivo lung perfusion using the Organ Care System in a porcine lung transplantation model
    Sommer, Wiebke
    Salman, Jawad
    Avsar, Murat
    Hoeffler, Klaus
    Jansson, Katharina
    Siemeni, Thierry N.
    Knoefel, Ann-Kathrin
    Ahrens, Linda
    Poyanmehr, Reza
    Tudorache, Igor
    Braubach, Peter
    Jonigk, Danny
    Haverich, Axel
    Warnecke, Gregor
    [J]. AMERICAN JOURNAL OF TRANSPLANTATION, 2019, 19 (02) : 345 - 355
12