Guest-host interactions of nanoconfined anti-cancer drug in metal-organic framework exposed by terahertz dynamics

被引：25
|
作者：
Souza, Barbara E. [1 ]
Rudic, Svemir [2 ]
Titov, Kirill [1 ]
Babal, Arun S. [1 ]
Taylor, James D. [2 ]
Tan, Jin-Chong [1 ]
机构：
[1] Univ Oxford, Dept Engn Sci, Multifunct Mat & Composites MMC Lab, Parks Rd, Oxford OX1 3PJ, England
[2] STFC Rutherford Appleton Lab, ISIS Facil, Didcot OX11 0QX, Oxon, England
来源：
CHEMICAL COMMUNICATIONS | 2019年 / 55卷 / 27期
关键词：
NEUTRON-SCATTERING; MOLECULES;
D O I：
10.1039/c8cc10089f
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A facile mechanochemical method was employed to accomplish one-pot encapsulation of anti-cancer drug 5-fluorouracil (5-FU as guest) in a metal-organic framework (HKUST-1 as host). Vibrational spectroscopy via inelastic neutron scattering was applied to probe guest-host interactions arising from nanoscale confinement. We compare 5-FU@HKUST-1 derived from in situ and ex situ encapsulation.
引用
收藏
页码：3868 / 3871
页数：4
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