Mitophagy in Cardiomyocytes and in Platelets: A Major Mechanism of Cardioprotection Against Ischemia/Reperfusion Injury

被引：47

作者：

Zhang, Weilin ^{[1
]}

Chen, Chuyan ^{[2
,3
]}

Wang, Jun ^{[1
]}

Liu, Lei ^{[1
]}

He, Yubin ^{[4
]}

Chen, Quan ^{[1
]}

机构：

[1] Chinese Acad Sci, Inst Zool, State Key Lab Membrane Biol, Beijing, Peoples R China

[2] Chinese Acad Med Sci, Beijing, Peoples R China

[3] Peking Union Med Coll, Sch Basic Med, Beijing, Peoples R China

[4] Chinese Army Gen Hosp, Heart Ctr, Dept Cardiol, Beijing, Peoples R China

来源：

PHYSIOLOGY | 2018年 / 33卷 / 02期

基金：

北京市自然科学基金;

关键词：

ISCHEMIA-REPERFUSION INJURY; PERMEABILITY TRANSITION PORE; CYTOCHROME-C-OXIDASE; P2Y(12) RECEPTOR ANTAGONIST; REACTIVE OXYGEN; MYOCARDIAL REPERFUSION; OXIDATIVE STRESS; MITOCHONDRIAL DYSFUNCTION; NLRP3; INFLAMMASOME; RESPIRATORY SUPERCOMPLEX;

D O I：

10.1152/physiol.00030.2017

中图分类号：

Q4 [生理学];

学科分类号：

071003 ;

摘要：

Mitophagy, a process that selectively removes damaged organelles by autolysosomal degradation, is an early cellular response to ischemia. Mitophagy is activated in both cardiomyocytes and platelets during ischemia/reperfusion (I/R) and heart disease conditions. We focus on the molecular regulation of mitophagy and highlight the role of mitophagy in cardioprotection.

引用

页码：86 / 98

页数：13

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