The Insulin-Like Growth Factors and Growth Disorders of Childhood

被引：14

作者：

Backeljauw, Philippe F. ^{[2
]}

Chernausek, Steven D. ^{[1
]}

机构：

[1] Univ Oklahoma, Hlth Sci Ctr, Dept Pediat, Oklahoma City, OK 73104 USA

[2] Univ Cincinnati, Cincinnati Childrens Hosp, Coll Med, Med Ctr,Dept Pediat, Cincinnati, OH 45229 USA

来源：

ENDOCRINOLOGY AND METABOLISM CLINICS OF NORTH AMERICA | 2012年 / 41卷 / 02期

关键词：

Growth hormone; Insulin-like growth factor; Short stature; GH receptor deficiency; Recombinant human insulin-like growth factor treatment; ACID-LABILE SUBUNIT; HORMONE INSENSITIVITY SYNDROME; IGF-BINDING PROTEIN-3; FACTOR-I RECEPTOR; IDIOPATHIC SHORT STATURE; SILVER-RUSSELL-SYNDROME; LONG-TERM TREATMENT; SHORT CHILDREN; FACTOR (IGF)-I; LARON-SYNDROME;

D O I：

10.1016/j.ecl.2012.04.010

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Specific lesions of the growth hormone (GH)/insulin-like growth factor (IGF) axis have been identified in humans, each of which has distinctive auxologic and biochemical features. Measures of circulating IGF-I are useful in diagnosing growth disorders in childhood and in evaluating response to OH therapy. Recombinant human IGF-I is an effective treatment of severe primary IGF deficiency, which is typical of patients with GH receptor defects (Laron syndrome). Such treatment has been limited to a few severely affected patients. Future studies will provide new insight into IGF-I as treatment and into the nature of growth disorders that involve the IGF axis.

引用

页码：265 / +

页数：19

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