Water-soluble two-photon absorbing-nitrosyl complex for light-activated therapy through nitric oxide release

被引：56

作者：

Zheng, Qingdong ^{[1
]}

Bonoiu, Adela ^{[1
]}

Ohulchanskyy, Tymish Y. ^{[1
]}

He, Guang S. ^{[1
]}

Prasad, Paras N. ^{[1
]}

机构：

[1] SUNY Buffalo, Dept Chem, Inst Lasers Photon & Biophoton, Buffalo, NY 14260 USA

来源：

MOLECULAR PHARMACEUTICS | 2008年 / 5卷 / 03期

关键词：

NO release; two-photon absorption; nitrosyl complex; light-dependent cytotoxicity;

D O I：

10.1021/mp700117s

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

A water-soluble nitrosyl complex with large two-photon absorption was synthesized by incorporating a two-photon absorbing chromophore with tetra(ethylene glycol) units, into the Roussin's red salt. The nitrosyl complex exhibits quenched emission due to energy transfer from the two-photon chromophore to the Roussin's red salt. The nitric oxide (NO) release induced by one- or two-photon irradiation was detected by EPR spectroscopy with a chemical probe, the Fe(II)-N-(dithiocarbamoyl)-N-methyl-D-glucamine (Fe-MGD) complex. Increased one- or two-photon excited fluorescence, with a concomitant photochemical release of NO, was observed upon one- or two-photon light irradiation. With the observed light-dependent cytotoxicity against cancer cells of the water-soluble nitrosyl complex, it was demonstrated that two-photon-functionalized nitrosyl complexes can be effective NO donors for light-activated treatment.

引用

页码：389 / 398

页数：10

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