Kidney Injury Molecule-1 (KIM-1): A specific and sensitive biomarker of kidney injury

被引：147
|
作者：
Bonventre, Joseph V. [1 ]
机构：
[1] Harvard Univ, Brigham & Womens Hosp, Sch Med,Inst Med, Dept Med,Renal Div, Boston, MA 02115 USA
来源：
SCANDINAVIAN JOURNAL OF CLINICAL & LABORATORY INVESTIGATION | 2008年 / 68卷
关键词：
transmembrane protein; proximal tubule; histopathology;
D O I：
10.1080/00365510802145059
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
There is an urgent need for the detection and monitoring of kidney injury in both the acute and chronic disease setting. Urinary kidney injury molecule-1 (Kim-1), a type-1 transmembrane protein, is not normally present, but is expressed on the proximal tubule apical membrane with injury. Kim-1 has proved to be an outstanding indicator of kidney injury in the rat, outperforming blood urea nitrogen and serum creatinine as predictors of histopathological changes in the proximal tubule in response to many pathophysiological states or toxicants. Studies in man indicate that tissue expression and urinary excretion of the ectodomain of KIM-1 are sensitive and specific markers of injury as well as predictors of outcome.
引用
收藏
页码：78 / 83
页数：6
相关论文
共 40 条
  • [21] Renal-specific loss of ferroportin disrupts iron homeostasis and attenuates recovery from acute kidney injury
    Soofi, Abdul
    Li, Vivie
    Beamish, Jeffrey A.
    Abdrabh, Sham
    Hamad, Mawieh
    Das, Nupur K.
    Shah, Yatrik M.
    Dressler, Gregory R.
    AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY, 2024, 326 (02) : F178 - F188
  • [22] Small Heat Shock Protein Beta-1 (HSPB1) Is Upregulated and Regulates Autophagy and Apoptosis of Renal Tubular Cells in Acute Kidney Injury
    Matsumoto, Tatsuki
    Urushido, Madoka
    Ide, Haruna
    Ishihara, Masayuki
    Hamada-Ode, Kazu
    Shimamura, Yoshiko
    Ogata, Koji
    Inoue, Kosuke
    Taniguchi, Yoshinori
    Taguchi, Takafumi
    Horino, Taro
    Fujimoto, Shimpei
    Terada, Yoshio
    PLOS ONE, 2015, 10 (05):
  • [23] Overexpressed SIRT6 attenuates cisplatin-induced acute kidney injury by inhibiting ERK1/2 signaling
    Li, Zhongchi
    Xu, Kang
    Zhang, Nannan
    Amador, Gabriel
    Wang, Yanying
    Zhao, Sen
    Li, Liyuan
    Qiu, Ying
    Wang, Zhao
    KIDNEY INTERNATIONAL, 2018, 93 (04) : 881 - 892
  • [24] Tubule-specific cyclin-dependent kinase 12 knockdown potentiates kidney injury through transcriptional elongation defects
    Zhang, Yi-Lin
    Tang, Tao-Tao
    Ni, Wei-Jie
    Li, Zhong-Tang
    Jiang, Liang-Yun-Zi
    Wang, Yao
    Zhou, Xuan
    Cao, Jing-Yuan
    Yin, Qing
    Jiang, Wei
    Zhao, Ya-Jie
    Gan, Wei-Hua
    Zhang, Ai-Qing
    Li, Zuo-Lin
    Wen, Yi
    Lv, Lin -Li
    Liu, Bi-Cheng
    Wang, Bin
    INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES, 2024, 20 (05): : 1669 - 1687
  • [25] Peroxisomal L-bifunctional Protein Deficiency Causes Male-specific Kidney Hypertrophy and Proximal Tubular Injury in Mice
    Ranea-Robles, Pablo
    Portman, Kensey
    Bender, Aaron
    Lee, Kyung
    He, John Cijiang
    Mulholland, David J.
    Argmann, Carmen
    Houten, Sander M.
    KIDNEY360, 2021, 2 (09): : 1441 - 1454
  • [26] Low-dose indomethacin after ischemic acute kidney injury prevents downregulation of Oat1/3 and improves renal outcome
    Schneider, R.
    Meusel, M.
    Renker, S.
    Bauer, C.
    Holzinger, H.
    Roeder, M.
    Wanner, C.
    Gekle, M.
    Sauvant, C.
    AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY, 2009, 297 (06) : F1614 - F1621
  • [27] Loss of renal tubular G9a benefits acute kidney injury by lowering focal lipid accumulation via CES1
    Yang, Dong
    Fan, Yu
    Xiong, Mingrui
    Chen, Yuchen
    Zhou, Yihao
    Liu, Xikai
    Yuan, Yangmian
    Wang, Qing
    Zhang, Yu
    Petersen, Robert B.
    Su, Hua
    Yue, Junqiu
    Zhang, Chun
    Chen, Hong
    Huang, Kun
    Zheng, Ling
    EMBO REPORTS, 2023, 24 (06)
  • [28] Bax and Bak have critical roles in ischemic acute kidney injury in global and proximal tubule-specific knockout mouse models
    Wei, Qingqing
    Dong, Guie
    Chen, Jian-Kang
    Ramesh, Ganesan
    Dong, Zheng
    KIDNEY INTERNATIONAL, 2013, 84 (01) : 138 - 148
  • [29] Proximal tubule-derived colony stimulating factor-1 mediates polarization of renal macrophages and dendritic cells, and recovery in acute kidney injury
    Wang, Yinqiu
    Chang, Jian
    Yao, Bing
    Niu, Aolei
    Kelly, Emily
    Breeggemann, Matthew C.
    Werner, Sherry L. Abboud
    Harris, Raymond C.
    Zhang, Ming-Zhi
    KIDNEY INTERNATIONAL, 2015, 88 (06) : 1274 - 1282
  • [30] Deletion of Multispecific Organic Anion Transporter Oat1/Slc22a6 Protects against Mercury-induced Kidney Injury
    Torres, Adriana M.
    Dnyanmote, Ankur V.
    Bush, Kevin T.
    Wu, Wei
    Nigam, Sanjay K.
    JOURNAL OF BIOLOGICAL CHEMISTRY, 2011, 286 (30) : 26391 - 26395
1234