Kidney Injury Molecule-1 (KIM-1): A specific and sensitive biomarker of kidney injury

被引：147
|
作者：
Bonventre, Joseph V. [1 ]
机构：
[1] Harvard Univ, Brigham & Womens Hosp, Sch Med,Inst Med, Dept Med,Renal Div, Boston, MA 02115 USA
来源：
SCANDINAVIAN JOURNAL OF CLINICAL & LABORATORY INVESTIGATION | 2008年 / 68卷
关键词：
transmembrane protein; proximal tubule; histopathology;
D O I：
10.1080/00365510802145059
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
There is an urgent need for the detection and monitoring of kidney injury in both the acute and chronic disease setting. Urinary kidney injury molecule-1 (Kim-1), a type-1 transmembrane protein, is not normally present, but is expressed on the proximal tubule apical membrane with injury. Kim-1 has proved to be an outstanding indicator of kidney injury in the rat, outperforming blood urea nitrogen and serum creatinine as predictors of histopathological changes in the proximal tubule in response to many pathophysiological states or toxicants. Studies in man indicate that tissue expression and urinary excretion of the ectodomain of KIM-1 are sensitive and specific markers of injury as well as predictors of outcome.
引用
收藏
页码：78 / 83
页数：6
相关论文
共 40 条
  • [1] Impact of Pathologists and Evaluation Methods on Performance Assessment of the Kidney Injury Biomarker, Kim-1
    Rouse, Rodney
    Min, Min
    Francke, Sabine
    Mog, Steven
    Zhang, Jun
    Shea, Katherine
    Stewart, Sharron
    Colatsky, Thomas
    TOXICOLOGIC PATHOLOGY, 2015, 43 (05) : 662 - 674
  • [2] Expression of kidney injury molecule-1 (Kim-1) in relation to necrosis and apoptosis during the early stages of Cd-induced proximal tubule injury
    Prozialeck, Walter C.
    Edwards, Joshua R.
    Lamar, Peter C.
    Liu, Jie
    Vaidya, Vishal S.
    Bonventre, Joseph V.
    TOXICOLOGY AND APPLIED PHARMACOLOGY, 2009, 238 (03) : 306 - 314
  • [3] Kidney injury molecule-1 identifies antemortem injury in postmortem adult and fetal kidney
    Yin, Wenqing
    Zhang, Ping L.
    Macknis, Jacqueline K.
    Lin, Fan
    Bonventre, Joseph, V
    AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY, 2018, 315 (06) : F1637 - F1643
  • [4] Expression of Kidney Injury Molecule-1 in Healthy and Diseased Feline Kidney Tissue
    Bland, S. K.
    Schmiedt, C. W.
    Clark, M. E.
    DeLay, J.
    Bienzle, D.
    VETERINARY PATHOLOGY, 2017, 54 (03) : 490 - 510
  • [5] Reduction of proteinuria in adriamycin-induced nephropathy is associated with reduction of renal kidney injury molecule (Kim-1) over time
    Kramer, Andrea B.
    van Timmeren, Mirjan M.
    Schuurs, Theo A.
    Vaidya, Vishal S.
    Bonventre, Joseph V.
    van Goor, Harry
    Navis, Gerjan
    AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY, 2009, 296 (05) : F1136 - F1145
  • [6] Donor kidney injury molecule-1 promotes graft recovery by regulating systemic necroinflammation
    Lee, Ji Yun
    Ismail, Ola Z.
    Zhang, Xizhong
    Haig, Aaron
    Lian, Dameng
    Gunaratnam, Lakshman
    AMERICAN JOURNAL OF TRANSPLANTATION, 2018, 18 (08) : 2021 - 2028
  • [7] Effects of Mineralocorticoid Receptor Blockade and Statins on Kidney Injury Marker 1 (KIM-1) in Female Rats Receiving L-NAME and Angiotensin II
    Huang, Jiayan
    Guzelce, Ezgi Caliskan
    Gholami, Shadi K.
    Gawelek, Kara L.
    Mitchell, Richard N.
    Pojoga, Luminita H.
    Romero, Jose R.
    Williams, Gordon H.
    Adler, Gail K.
    INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2023, 24 (07)
  • [8] Urinary Kidney Injury Molecule-1 but Not Urinary Neutrophil Gelatinase Associated Lipocalin Is Increased after Short Maximal Exercise
    Wolyniec, Wojciech
    Ratkowski, Wojciech
    Urbanski, Robert
    Bartoszewicz, Maria
    Siluk, Danuta
    Wolyniec, Zuzanna
    Kasprowicz, Katarzyna
    Zorena, Katarzyna
    Renke, Marcin
    NEPHRON, 2018, 138 (01) : 29 - 34
  • [9] Angiotensinogen as a biomarker of acute kidney injury
    Aqeel, Sheeba Habeeb Ba
    Sanchez, Alejandro
    Batlle, Daniel
    CLINICAL KIDNEY JOURNAL, 2017, 10 (06): : 759 - 768
  • [10] Regression of microalbuminuria in type 1 diabetes is associated with lower levels of urinary tubular injury biomarkers, kidney injury molecule-1, and N-acetyl-β-D-glucosaminidase
    Vaidya, Vishal S.
    Niewczas, Monika A.
    Ficociello, Linda H.
    Johnson, Amanda C.
    Collings, Fitz B.
    Warram, James H.
    Krolewski, Andrzej S.
    Bonventre, Joseph V.
    KIDNEY INTERNATIONAL, 2011, 79 (04) : 464 - 470
1234