Less is more? STI in acute and chronic HIV-1 infection

被引:40
作者
Altfeld, M [1 ]
Walker, BD
机构
[1] Massachusetts Gen Hosp, Partners AIDS Res Ctr, Boston, MA 02114 USA
[2] Harvard Univ, Sch Med, Boston, MA USA
关键词
D O I
10.1038/90901
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Emerging data has indicated that supervised treatment interruption (STI) of highly active antiretroviral therapy might significantly augment immune responses in HIV-1-infected patients and slow disease progression. Here the authors discuss the rationale behind STI and future directions for study.
引用
收藏
页码:881 / 884
页数:4
相关论文
共 54 条
[31]   Natural history of human immunodeficiency virus type 1 viremia after seroconversion and proximal to AIDS in a large cohort of homosexual men [J].
Lyles, RH ;
Muñoz, A ;
Yamashita, TE ;
Bazmi, H ;
Detels, R ;
Rinaldo, CR ;
Margolick, JB ;
Phair, JP ;
Mellors, JW .
JOURNAL OF INFECTIOUS DISEASES, 2000, 181 (03) :872-880
[32]   Effect of combination antiretroviral therapy on T-cell immunity in acute human immunodeficiency virus type 1 infection [J].
Malhotra, U ;
Berrey, MM ;
Huang, YJ ;
Markee, J ;
Brown, DJ ;
Ap, S ;
Musey, L ;
Schacker, T ;
Corey, L ;
McElrath, MJ .
JOURNAL OF INFECTIOUS DISEASES, 2000, 181 (01) :121-131
[33]  
MARKOWITZ M, 2001, 8 C RETR OPP INF CHI
[34]   Cellular immune responses to HIV [J].
McMichael, AJ ;
Rowland-Jones, SL .
NATURE, 2001, 410 (6831) :980-987
[35]   HLA B*5701 is highly associated with restriction of virus replication in a subgroup of HIV-infected long term nonprogressors [J].
Migueles, SA ;
Sabbaghian, MS ;
Shupert, WL ;
Bettinotti, MP ;
Marincola, FM ;
Martino, L ;
Hallahan, CW ;
Selig, SM ;
Schwartz, D ;
Sullivan, J ;
Connors, M .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2000, 97 (06) :2709-2714
[36]   Structured treatment interruptions in antiretroviral management of HIV-1 [J].
Miller, V .
CURRENT OPINION IN INFECTIOUS DISEASES, 2001, 14 (01) :29-37
[37]   Virological and immunological effects of treatment interruptions in HIV-1 infected patients with treatment failure [J].
Miller, V ;
Sabin, C ;
Hertogs, K ;
Bloor, S ;
Martinez-Picado, J ;
D'Aquila, R ;
Larder, B ;
Lutz, T ;
Gute, P ;
Weidmann, E ;
Rabenau, H ;
Phillips, A ;
Staszewski, S .
AIDS, 2000, 14 (18) :2857-2867
[38]   Structured treatment interruptions to control HIV-1 and limit drug exposure [J].
Montaner, LJ .
TRENDS IN IMMUNOLOGY, 2001, 22 (02) :92-96
[39]   HIV-1 rebound during interruption of highly active antiretroviral therapy has no deleterious effect on reinitiated treatment [J].
Neumann, AU ;
Tubiana, R ;
Calvez, V ;
Robert, C ;
Li, TS ;
Agut, H ;
Autran, B ;
Katlama, C .
AIDS, 1999, 13 (06) :677-683
[40]   Quantitation of HIV-1-specific cytotoxic T lymphocytes and plasma load of viral RNA [J].
Ogg, GS ;
Jin, X ;
Bonhoeffer, S ;
Dunbar, PR ;
Nowak, MA ;
Monard, S ;
Segal, JP ;
Cao, YZ ;
Rowland-Jones, SL ;
Cerundolo, V ;
Hurley, A ;
Markowitz, M ;
Ho, DD ;
Nixon, DF ;
McMichael, AJ .
SCIENCE, 1998, 279 (5359) :2103-2106