Less is more? STI in acute and chronic HIV-1 infection

被引：40

作者：

Altfeld, M ^{[1
]}

Walker, BD

机构：

[1] Massachusetts Gen Hosp, Partners AIDS Res Ctr, Boston, MA 02114 USA

[2] Harvard Univ, Sch Med, Boston, MA USA

来源：

NATURE MEDICINE | 2001年 / 7卷 / 08期

关键词：

D O I：

10.1038/90901

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Emerging data has indicated that supervised treatment interruption (STI) of highly active antiretroviral therapy might significantly augment immune responses in HIV-1-infected patients and slow disease progression. Here the authors discuss the rationale behind STI and future directions for study.

引用

页码：881 / 884

页数：4

共 54 条

[1] The role of CD4+ T helper cells in the cytotoxic T lymphocyte response to HIV-1 [J].

Altfeld, M ;

Rosenberg, ES .

CURRENT OPINION IN IMMUNOLOGY, 2000, 12 (04) :375-380

[2] Cellular immune responses and viral diversity in individuals treated during acute and early HIV-1 infection [J].

Altfeld, M ;

Rosenberg, ES ;

Shankarappa, R ;

Mukherjee, JS ;

Hecht, FM ;

Eldridge, RL ;

Addo, MM ;

Poon, SH ;

Phillips, MN ;

Robbins, GK ;

Sax, PE ;

Boswell, S ;

Kahn, JO ;

Brander, C ;

Goulder, PJR ;

Levy, JA ;

Mullins, JI ;

Walker, BD .

JOURNAL OF EXPERIMENTAL MEDICINE, 2001, 193 (02) :169-180

[3] Control of a mucosal challenge and prevention of AIDS by a multiprotein DNA/MVA vaccine [J].

Amara, RR ;

Villinger, F ;

Altman, JD ;

Lydy, SL ;

O'Neil, SP ;

Staprans, SI ;

Montefiori, DC ;

Xu, Y ;

Herndon, JG ;

Wyatt, LS ;

Candido, MA ;

Kozyr, NL ;

Earl, PL ;

Smith, JM ;

Ma, HL ;

Grimm, BD ;

Hulsey, ML ;

Miller, J ;

McClure, HM ;

McNicholl, JM ;

Moss, B ;

Robinson, HL .

SCIENCE, 2001, 292 (5514) :69-74

[4] Positive effects of combined antiretroviral therapy on CD4(+) T cell homeostasis and function in advanced HIV disease [J].

Autran, B ;

Carcelain, G ;

Li, TS ;

Blanc, C ;

Mathez, D ;

Tubiana, R ;

Katlama, C ;

Debre, P ;

Leibowitch, J .

SCIENCE, 1997, 277 (5322) :112-116

[5] Control of viremia and prevention of clinical AIDS in rhesus monkeys by cytokine-augmented DNA vaccination [J].

Barouch, DH ;

Santra, S ;

Schmitz, JE ;

Kuroda, MJ ;

Fu, TM ;

Wagner, W ;

Bilska, M ;

Craiu, A ;

Zheng, XX ;

Krivulka, GR ;

Beaudry, K ;

Lifton, MA ;

Nickerson, CE ;

Trigona, WL ;

Punt, K ;

Freed, DC ;

Guan, LM ;

Dubey, S ;

Casimiro, D ;

Simon, A ;

Davies, ME ;

Chastain, M ;

Strom, TB ;

Gelman, RS ;

Montefiori, DC ;

Lewis, MG ;

Emini, EA ;

Shiver, JW ;

Letvin, NL .

SCIENCE, 2000, 290 (5491) :486-492

[6] INFLUENZA VIRUS-INFECTED DENDRITIC CELLS STIMULATE STRONG PROLIFERATIVE AND CYTOLYTIC RESPONSES FROM HUMAN CD8+ T-CELLS [J].

BHARDWAJ, N ;

BENDER, A ;

GONZALEZ, N ;

BUI, LK ;

GARRETT, MC ;

STEINMAN, RM .

JOURNAL OF CLINICAL INVESTIGATION, 1994, 94 (02) :797-807

[7] Proliferative responses to human immunodeficiency virus type 1 (HIV-1) antigens in HIV-1-infected patients with immune reconstitution [J].

Blankson, JN ;

Gallant, JE ;

Siliciano, RF .

JOURNAL OF INFECTIOUS DISEASES, 2001, 183 (04) :657-661

[8] HLA and HIV-1:: Heterozygote advantage and B*35-Cw*04 disadvantage [J].

Carrington, M ;

Nelson, GW ;

Martin, MP ;

Kissner, T ;

Vlahov, D ;

Goedert, JJ ;

Kaslow, R ;

Buchbinder, S ;

Hoots, K ;

O'Brien, SJ .

SCIENCE, 1999, 283 (5408) :1748-1752

[9] Retroviral rebound syndrome after cessation of suppressive antiretroviral therapy in three patients with chronic HIV infection [J].

Colven, R ;

Harrington, RD ;

Spach, DH ;

Cohen, CJ ;

Hooton, TM .

ANNALS OF INTERNAL MEDICINE, 2000, 133 (06) :430-434

[10] HIV-1 and T cell dynamics after interruption of highly active antiretroviral therapy (HAART) in patients with a history of sustained viral suppression [J].

Davey, RT ;

Bhat, N ;

Yoder, C ;

Chun, TW ;

Metcalf, JA ;

Dewar, R ;

Natarajan, V ;

Lempicki, RA ;

Adelsberger, JW ;

Millers, KD ;

Kovacs, JA ;

Polis, MA ;

Walker, RE ;

Falloon, L ;

Masur, H ;

Gee, D ;

Baseler, M ;

Dimitrov, DS ;

Fauci, AS ;

Lane, HC .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1999, 96 (26) :15109-15114

← 1 2 3 4 5 6 →