Pectin in cancer therapy: A review

被引：174

作者：

Zhang, Wenbo ^{[1
]}

Xu, Ping ^{[2
]}

Zhang, Han ^{[1
]}

机构：

[1] Xinxiang Med Univ, Sch Life Sci & Technol, Xinxiang 453003, Henan, Peoples R China

[2] Xinxiang Med Univ, Sch Pharm, Xinxiang 453003, Henan, Peoples R China

来源：

TRENDS IN FOOD SCIENCE & TECHNOLOGY | 2015年 / 44卷 / 02期

关键词：

MODIFIED CITRUS PECTIN; APOPTOSIS CASCADE PROTEINS; RAT COLON CARCINOGENESIS; IN-VIVO EVALUATION; CELL-CYCLE ARREST; PROSTATE-CANCER; ACIDIC POLYSACCHARIDE; RHAMNOGALACTURONAN-I; EPITHELIAL-CELLS; MELANOMA-CELLS;

D O I：

10.1016/j.tifs.2015.04.001

中图分类号：

TS2 [食品工业];

学科分类号：

0832 ;

摘要：

Pectin, a complex class of plant polysaccharides, is composed of a galacturonan backbone and neutral sugar side chains. Natural pectin is reported to prevent colon cancer as a dietary fiber (DF). To enhance its bioavailability and bioactivity, pectin was modified into bioavailable modified pectin fragments (MPs) with low molecular mass. Also, MPs had low degrees of esterification (DE) which is reported to inhibit tumor growth, induce apoptosis, suppress metastasis, and modulate immunological responses. Antitumor activity of MPs chiefly arises from intervention in ligand recognition by galectin-3 (Gal-3). In addition, pectin is a suitable vehicle for anti-cancer drug delivery systems, due to its abundant modifiable functional groups and special physicochemical properties. Here, we summarize the structural features, bio-absorption and antitumor mechanisms and the structure-activity relationship of MPs. We also offer prospects and challenges for developing pectin into nutraceuticals or drugs.

引用

页码：258 / 271

页数：14

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