Long-term treatment of invasive sinus, tracheobroncheal, pulmonary and intracerebral aspergillosis in acute lymphoblastic leukaemia

被引：6

作者：

Bjorkholm, M. ^{[1
,2
]}

Kalin, M. ^{[3
]}

Grane, P. ^{[4
]}

Celsing, F. ^{[2
]}

机构：

[1] Karolinska Univ Hosp Solna, Div Hematol, Dept Med, SE-17176 Stockholm, Sweden

[2] Karolinska Univ Hosp & Inst, Div Hematol, Dept Med, Stockholm, Sweden

[3] Karolinska Univ Hosp & Inst, Div Infect Dis, Stockholm, Sweden

[4] Karolinska Univ Hosp & Inst, Dept Clin Neurosci, Neuroradiol Sect, Stockholm, Sweden

来源：

INFECTION | 2012年 / 40卷 / 01期

关键词：

Acute Lymphoblastic Leukemia; Voriconazole; Aspergillosis; Invasive Aspergillosis; Posaconazole;

D O I：

10.1007/s15010-011-0158-9

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

A 59-year-old male with acute lymphoblastic leukemia developed sinus, tracheobroncheal, pulmonary, and intracerebral aspergillosis. All lesions except the intracerebral aspergillosis healed after combination antifungal treatment. Long-term voriconazole but not posaconazole therapy induced partial regression of the cerebral manifestations. At the time of writing, 3.5 years after the initial diagnosis, the patient is working half-time and suffers from a possible voriconazole-induced polyneuropathy.

引用

页码：81 / 85

页数：5

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