Analytical methodologies for the determination of cisplatin

被引：83
作者：
Espinosa Bosch, M. [3 ]
Ruiz Sanchez, A. J. [2 ]
Sanchez Rojas, F. [1 ]
Bosch Ojeda, C. [1 ]
机构：
[1] Univ Malaga, Fac Sci, Dept Analyt Chem, E-29071 Malaga, Spain
[2] Univ Malaga, Fac Sci, Dept Organ Chem, E-29071 Malaga, Spain
[3] Univ Hosp Virgen del Rocio, Dept Pharm, Gen Hosp, Seville 41013, Spain
来源：
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS | 2008年 / 47卷 / 03期
关键词：
cisplatin; pharmaceutical analysis; review; analytical methodologies;
D O I：
10.1016/j.jpba.2008.01.047
中图分类号：
O65 [分析化学];
学科分类号：
070302 ; 081704 ;
摘要：
cis-Diamminedichloroplatinum(II) (cisplatin) is a important chemotherapeutic drug for cancer treatment since 1978. Unfortunately, because of the severe side-effects like nephrotoxicity, ototoxicity, etc., they are administered in small doses at low concentration establishing the maximum limit dosage to 100 mg/m(2) (21 days). A variety of analytical methods have been proposed for the determination of cisplatin in biological fluids and tissues that permit the accurate determination at or below the part per billion level in the native sample. The purpose of the current review is to provide a systematic survey of the latest analytical techniques for the determination of cisplatin in biological samples. (C) 2008 Elsevier B.V. All rights reserved.
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收藏
页码：451 / 459
页数：9
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