Design, Synthesis, and Evaluation of Thiol-Activated Sources of Sulfur Dioxide (SO2) as Antimycobacterial Agents

被引：163

作者：

Malwal, Satish R. ^{[1
]}

Sriram, Dharmarajan ^{[2
]}

Yogeeswari, Perumal ^{[2
]}

Konkimalla, V. Badireenath ^{[3
]}

Chakrapani, Harinath ^{[1
]}

机构：

[1] Indian Inst Sci Educ & Res, Dept Chem, Pune 411008, Maharashtra, India

[2] Birla Inst Technol & Sci Pilani, Dept Pharm, Hyderabad 500078, Andhra Pradesh, India

[3] NISER, Sch Biol Sci, Bhubaneswar 751005, Orissa, India

来源：

JOURNAL OF MEDICINAL CHEMISTRY | 2012年 / 55卷 / 01期

关键词：

NITRIC-OXIDE; MYCOBACTERIUM-TUBERCULOSIS; THERAPEUTIC AGENTS; MEAT-PRODUCTS; !text type='JS']JS[!/text]-K; SULFITE; FRESH; INHALATION; MECHANISM; SYSTEM;

D O I：

10.1021/jm201023g

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Here, 2,4-dinitrophenylsulfonamides with tunable cysteine-activated SO2 release profiles with half-lives of SO2 release varying from 2 to 63 min are reported. N-Benzyl-2,4-dinitrobenzenesulfonamide (6), which is prepared in one step from commercial sources, had a potency (MIC = 0.15 mu M) of inhibiting Mycobacterium tuberculosis (Mtb) higher than the clinical agent isoniazid (MIC = 0.37 mu M).

引用

页码：553 / 557

页数：5

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