Normal reference ranges of optical coherence tomography parameters in childhood

Objective To report normal reference values for peripapillary retinal nerve fibre layer (RNFL) thickness and optic disc parameters in children from a community population. Methods The authors performed a cross-sectional study examining RNFL and optic nerve head (ONH) properties in 358 children aged between 6 and 13 years with no ocular disease. All children underwent an ophthalmic examination that included visual acuity (logMAR), stereopsis assessment (TNO) and optical coherence tomography (Cirrus OCT Zeiss, 'Optic Disc Cube 200x200' protocol). One eye from each subject selected at random was finally analysed. The authors evaluated the influence of height, gender and age on measurements. Results High-quality scan data were obtained from 357 children and 344 were finally included. The mean age (SD) was 9.16 (1.7) years and the mean (SD) RNFL average thickness was 98.46 (10.79) mu m. The temporal quadrant showed the thinnest RNFL (69.35 +/- 11.28 mu m), followed by the nasal (71.30 +/- 13.45 mu m), superior (123.65 +/- 19.49 mu m) and inferior (130.18 +/- 18.13 mu m) quadrants. The mean rim area (SD) and disc area (SD) were 1.59 (0.33) and 2.05 (0.39) mm(2), respectively. The average cup to disc (C:D) ratio (SD) was 0.43 (0.19). The authors found no differences in any of the parameters with regard to weight, height and gender. Conclusions This study demonstrates normative values of RNFL thickness and ONH parameters in a sample of Caucasian children from the general population.