The neonatal Fc receptor does not modulate hepatitis C virus neutralization

被引：4
作者：
Morel, Anthony [1 ,2 ]
Passot, Christophe [2 ,3 ]
Arnoult, Christophe [2 ,3 ]
Dumans, Amelie [1 ,2 ]
Beaumont, Elodie [1 ,2 ]
Gouilleux-Gruart, Valerie [2 ,3 ]
Roingeard, Philippe [1 ,2 ]
Blanchard, Emmanuelle [1 ,2 ]
机构：
[1] Univ Tours, INSERM, U966, F-37041 Tours, France
[2] CHRU Tours, Tours, France
[3] Univ Tours, CNRS, UMR 7292, F-37041 Tours, France
来源：
JOURNAL OF GENERAL VIROLOGY | 2015年 / 96卷
关键词：
INFECTION; ANTIBODIES; CELLS; IGG; PROTECT;
D O I：
10.1099/vir.0.000060
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
The neonatal Fc receptor (FcRn) is the only receptor known to be able to transport IgG across cell barriers and may therefore modulate virus infection. FcRn is expressed efficiently in hepatocytes. We therefore investigated the possible involvement of an FcRn-dependent mechanism in hepatitis C virus (HCV) neutralization. Our study, in both HCV pseudoparticles and HCV in cell-culture models, showed that FcRn was not involved in the intracellular neutralization of HCV, in contrast to the situation observed for influenza A virus.
引用
收藏
页码：1062 / 1066
页数：5
相关论文
共 16 条
  • [1] Neonatal FcR expression in bone marrow-derived cells functions to protect serum IgG from catabolism
    Akilesh, Shreeram
    Christianson, Gregory J.
    Roopenian, Derry C.
    Shaw, Andrey S.
    [J]. JOURNAL OF IMMUNOLOGY, 2007, 179 (07) : 4580 - 4588
  • [2] Intracellular neutralization of viral infection in polarized epithelial cells by neonatal Fc receptor (FcRn)-mediated IgG transport
    Bai, Yu
    Ye, Lilin
    Tesar, Devin B.
    Song, Haichen
    Zhao, Deming
    Bjoerkman, Pamela J.
    Roopenian, Derry C.
    Zhu, Xiaoping
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2011, 108 (45) : 18406 - 18411
  • [3] Infectious hepatitis C virus pseudo-particles containing functional E1-E2 envelope protein complexes
    Bartosch, B
    Dubuisson, J
    Cosset, FL
    [J]. JOURNAL OF EXPERIMENTAL MEDICINE, 2003, 197 (05) : 633 - 642
  • [4] A genetically humanized mouse model for hepatitis C virus infection
    Dorner, Marcus
    Horwitz, Joshua A.
    Robbins, Justin B.
    Barry, Walter T.
    Feng, Qian
    Mu, Kathy
    Jones, Christopher T.
    Schoggins, John W.
    Catanese, Maria Teresa
    Burton, Dennis R.
    Law, Mansun
    Rice, Charles M.
    Ploss, Alexander
    [J]. NATURE, 2011, 474 (7350) : 208 - U246
  • [5] Human broadly neutralizing antibodies to the envelope glycoprotein complex of hepatitis C virus
    Giang, Erick
    Dorner, Marcus
    Prentoe, Jannick C.
    Dreux, Marlene
    Evans, Matthew J.
    Bukh, Jens
    Rice, Charles M.
    Ploss, Alexander
    Burton, Dennis R.
    Law, Mansun
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2012, 109 (16) : 6205 - 6210
  • [6] Human serum facilitates hepatitis C virus infection, and neutralizing responses inversely correlate with viral replication kinetics at the acute phase of hepatitis C virus infection
    Lavillette, D
    Morice, Y
    Germanidis, G
    Donot, P
    Soulier, A
    Pagkalos, E
    Sakellariou, G
    Intrator, L
    Bartosch, B
    Pawlotsky, JM
    Cosset, FL
    [J]. JOURNAL OF VIROLOGY, 2005, 79 (10) : 6023 - 6034
  • [7] Broadly neutralizing antibodies protect against hepatitis C virus quasispecies challenge
    Law, Mansun
    Maruyama, Toshiaki
    Lewis, Jamie
    Giang, Erick
    Tarr, Alexander W.
    Stamataki, Zania
    Gastaminza, Pablo
    Chisari, Francis V.
    Jones, Ian M.
    Fox, Robert I.
    Ball, Jonathan K.
    McKeating, Jane A.
    Kneteman, Norman M.
    Burton, Dennis R.
    [J]. NATURE MEDICINE, 2008, 14 (01) : 25 - 27
  • [8] On the History of Hepatitis C Virus Cell Culture Systems
    Lohmann, Volker
    Bartenschlager, Ralf
    [J]. JOURNAL OF MEDICINAL CHEMISTRY, 2014, 57 (05) : 1627 - 1642
  • [9] Rapid induction of virus-neutralizing antibodies and viral clearance in a single-source outbreak of hepatitis C
    Pestka, Jan M.
    Zeisel, Mirjam B.
    Blaeser, Edith
    Schuermann, Peter
    Bartosch, Birke
    Cosset, Francois-Loic
    Patel, Arvind H.
    Meisel, Helga
    Baumert, Jens
    Viazov, Sergei
    Rispeter, Kay
    Blum, Hubert E.
    Roggendorf, Michael
    Baumert, Thomas F.
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2007, 104 (14) : 6025 - 6030
  • [10] ANALYSIS OF THE PH-DEPENDENCE OF THE NEONATAL FC RECEPTOR IMMUNOGLOBULIN-G INTERACTION USING ANTIBODY AND RECEPTOR VARIANT
    RAGHAVAN, M
    BONAGURA, VR
    MORRISON, SL
    BJORKMAN, PJ
    [J]. BIOCHEMISTRY, 1995, 34 (45) : 14649 - 14657
12