NEW SEMISYNTHETIC DERIVATIVES OF A BENZYLISOTHIOCYANATE ISOLATED FROM Moringa oleifera AND EVALUATION OF THEIR CYTOTOXIC ACTIVITY

被引：4

作者：

de Almeida, Diana Kelly C. ^{[1
]}

da Silva, Marcos R. ^{[1
]}

de Oliveira, Maria Conceicao F. ^{[1
]}

Mafezoli, Jair ^{[1
]}

de Mattos, Marcos C. ^{[1
]}

Moura, AndrA F. ^{[2
]}

Moraes Filho, Manoel O. ^{[2
]}

Barbosa, Francisco G. ^{[1
]}

机构：

[1] Univ Fed Ceara, Dept Quim Organ & Inorgan, BR-60455970 Fortaleza, Ceara, Brazil

[2] Univ Fed Ceara, Dept Fisiol & Farmacol, BR-60430270 Fortaleza, Ceara, Brazil

来源：

QUIMICA NOVA | 2017年 / 40卷 / 10期

关键词：

benzylisothiocyanate; Moringa oleifera; cytotoxic activity; semisynthetic derivatives; IN-VITRO; ANTIOXIDANT ACTIVITY; CANCER CELLS; ISOTHIOCYANATE; LEAVES; PROLIFERATION; GLYCOSIDES; TOXICITY; EXTRACTS; PROMOTER;

D O I：

10.21577/0100-4042.20170132

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

From the natural product 4-(4'-O-acetyl-a-L-rhamnosyloxy) benzylisothiocyanate (1), isolated from the flowers of Moringa oleifera Lam (Moringaceae), four new semisynthetic derivatives, N-[4-(4'-O-acetyl-alpha-L-rhamnosyloxy) benzyl]-2-(pyridinil-4-carbonil) hydrazine-1-carbothioamide (3), 4-(4'-O-acetyl-2', 3'-dimesyloxy-alpha-L-rhamnosyloxy) benzylisothiocyanate (4), N-[(4'-O-acetyl-alpha-Lrhamnosyloxy) benzyl] hydrazinecarbothioamide (5), 4-[4'-O-acetyl-2', 3'-O-bis(decanoiloxy)-alpha-L-rhamnosyloxy] benzylisothiocianate (6), and the known compound 4-(2', 3', 4'-O-triacetyl-alpha-L-rhamnosyloxy) benzylisothiocyanate (2), were obtained. All compounds were tested for their cytotoxicity against the tumor cell lines SF-295, HL-60, HCT-116 e PC-3. The natural product 1 and the semisynthetic derivatives 2 and 4 were the most active compounds (IC50 from 16.0 to 3.7 mu mol L-1) against all tumor cell lines.

引用

页码：1186 / 1190

页数：5

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