The next level of complexity: post-transcriptional regulation by microRNAs

被引：6
|
作者：
Kramann, Rafael [2 ]
Moeller, Marcus J. [1 ,2 ]
机构：
[1] Univ Hosp Aachen, Dept Nephrol & Clin Immunol, D-52057 Aachen, Germany
[2] Aachen Univ Technol RWTH, Univ Hosp, Div Nephrol & Immunol, Aachen, Germany
来源：
KIDNEY INTERNATIONAL | 2011年 / 80卷 / 07期
关键词：
SMALL RNAS; DELETION;
D O I：
10.1038/ki.2011.175
中图分类号：
R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];
学科分类号：
1002 ; 100201 ;
摘要：
MicroRNAs (miRNAs) are endogenous, small, noncoding RNAs that regulate expression of about half of human genes. Canonical miRNA biosynthesis involves two RNase III-type proteins, Drosha and Dicer. A podocyte-specific knockout of Dicer resulted in foot process effacement. In this issue, Zhdanova et al. report on targeting Drosha in a podocyte-specific fashion. Their study demonstrates an essential role of canonical miRNAs in maintaining the fully differentiated podocyte phenotype.
引用
收藏
页码：692 / 693
页数：2
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