Changes of regulatory T cells, transforming growth factor-beta and interleukin-10 in patients with type 1 diabetes mellitus: A systematic review and meta-analysis

被引：24

作者：

Qiao, Yong-chao ^{[1
,3
]}

Shen, Jian ^{[2
]}

Hong, Xue-zhi ^{[2
]}

Liang, Ling ^{[1
,2
]}

Bo, Chao-sheng ^{[1
,2
]}

Sui, Yi ^{[2
]}

Zhao, Hai-lu ^{[1
,2
,3
]}

机构：

[1] Guilin Med Univ, Fac Basic Med, Dept Immunol, Guilin 541004, Peoples R China

[2] Guilin Med Univ, Guangxi Key Lab Excellence, Diabet Syst Med, Guilin 541004, Peoples R China

[3] Cent S Univ, Dept Immunol, Sch Basic Med Sci, Changsha 410078, Hunan, Peoples R China

来源：

CLINICAL IMMUNOLOGY | 2016年 / 170卷

基金：

中国国家自然科学基金;

关键词：

Type I diabetes mellitus; Regulatory T cells; Transforming growth factor-beta; Interleukin-10; Meta-analysis; RESPONSES; PATHOGENESIS; SUPPRESSION; DEFECTS; FOXP3; RISK;

D O I：

10.1016/j.clim.2016.08.004

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Regulatory T lymphocyte cells (Treg) associated with interleukin-10 (IL-10) and transforming growth factor-beta (TGF-beta) have implicated in the development of type 1 diabetes mellitus (T1DM), yet the existing evidence remains unclear. Hereby we performed a systematic review and meta-analysis to characterize the changes in T1DM patients. A total of 1407 T1DM patients and 1373 healthy controls from 40 case-control studies were eventually included in the pooling analysis. Compared with the controls, T1DM patients had decreased frequency of CD4(+)CD25(+)Treg (p = 0.0003), CD4(+)CD25(+)Foxp3(+)Treg (p = 0.020), and the level of TGF-beta (p = 0.030). Decrease in IL-10 (p = 0.14) was not significant. All the changes remained significant when the studies with low NOS scores and publication bias were excluded. In conclusion, peripheral Treg and serum TGF-beta are reduced in type 1 diabetes mellitus whereas changes in serum IL-10 are not significant. (C) 2016 Elsevier Inc. All rights reserved.

引用

页码：61 / 69

页数：9