Synthesis of sodium alginate based sprayable new soft gel system

被引：29
作者：
Chhatbar, Mahesh U. [1 ]
Prasad, Kamalesh [1 ]
Chejara, Dharmesh R. [1 ]
Siddhanta, A. K. [1 ]
机构：
[1] CSIR, CSIR Cent Salt & Marine Chem Res Inst, Marine Biotechnol & Ecol Discipline, Bhavnagar 364021, Gujarat, India
来源：
SOFT MATTER | 2012年 / 8卷 / 06期
关键词：
RHEOLOGICAL PROPERTIES; HYDROLYSIS; CONJUGATE; MATRIX;
D O I：
10.1039/c2sm06947d
中图分类号：
O64 [物理化学（理论化学）、化学物理学];
学科分类号：
070304 ; 081704 ;
摘要：
Chemical reaction of sodium alginate (Na-Alg) with o-aminobenzoic acid (OABA) and m-aminobenzoic acid (MABA) in the presence of 1-ethyl-3-[3-(dimethylamino)propyl]-carbodiimide hydrochloride (EDC) afforded amide derivatives capable of forming viscous hydrogel systems exhibiting thixotropic behaviour. Characterization of the amide materials was done by employing FT-IR and C-13 NMR, wherein amide formation between Na-Alg and OABA or MABA was confirmed. The thixotropic behaviour was evaluated by rheology and viscometry showing superior thixotropicity of OABA based amide to its MABA counterpart. The characteristic of the soft gel turning into a flowing liquid on gentle stirring predisposes it for possible application as a delivery system or sprayable gel material for transporting small active molecules to the targeted locations in health and personal care formulations.
引用
收藏
页码：1837 / 1844
页数：8
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