Genetic variability of principal neutralizing determinants on HIV-1 gp41 and its correlation with subtypes

被引：6

作者：

Dong, XN ^{[1
]}

Ying, H ^{[1
]}

Wu, Y ^{[1
]}

Chen, YH ^{[1
]}

机构：

[1] Tsing Hua Univ, Immunol Lab, Dept Biol, Prot Sci Lab MOE, Beijing 100084, Peoples R China

来源：

IMMUNOLOGY LETTERS | 2005年 / 101卷 / 01期

关键词：

HIV-1; gp41; genetic variability; subtype; neutralizing epitopes;

D O I：

10.1016/j.imlet.2005.04.013

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Several neutralizing determinants have been identified on HIV-1 envelope glycoprotein gp41: LGIWGCSGKLIC (HXB2: aa593-604), ELDKWA (aa662-667), NWFDIT (aa671-676), and ERDRDR (aa739-744). Restricted mutations were observed on these epitopes. In this study, the genetic variability of these neutralizing determinants in 3799 isolates from different M-group subtypes (A, B, C, D, F, G, H, CRF01_AE and CRF02_AG) and 0 group was analyzed. Many variants were found to be closely correlated with certain subtypes. These subtype-related variants could be recruited into the subtype identification and subtype-specific vaccine development. (c) 2005 Elsevier B.V. All rights reserved.

引用

页码：104 / 107

页数：4

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