Genetic variability of principal neutralizing determinants on HIV-1 gp41 and its correlation with subtypes

被引：6

作者：

Dong, XN ^{[1
]}

Ying, H ^{[1
]}

Wu, Y ^{[1
]}

Chen, YH ^{[1
]}

机构：

[1] Tsing Hua Univ, Immunol Lab, Dept Biol, Prot Sci Lab MOE, Beijing 100084, Peoples R China

来源：

IMMUNOLOGY LETTERS | 2005年 / 101卷 / 01期

关键词：

HIV-1; gp41; genetic variability; subtype; neutralizing epitopes;

D O I：

10.1016/j.imlet.2005.04.013

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Several neutralizing determinants have been identified on HIV-1 envelope glycoprotein gp41: LGIWGCSGKLIC (HXB2: aa593-604), ELDKWA (aa662-667), NWFDIT (aa671-676), and ERDRDR (aa739-744). Restricted mutations were observed on these epitopes. In this study, the genetic variability of these neutralizing determinants in 3799 isolates from different M-group subtypes (A, B, C, D, F, G, H, CRF01_AE and CRF02_AG) and 0 group was analyzed. Many variants were found to be closely correlated with certain subtypes. These subtype-related variants could be recruited into the subtype identification and subtype-specific vaccine development. (c) 2005 Elsevier B.V. All rights reserved.

引用

页码：104 / 107

页数：4

共 50 条

[21] Trilobatin as an HIV-1 entry inhibitor targeting the HIV-1 Gp41 envelope
Yin, Shuwen
Zhang, Xuanxuan
Lai, Fangyuan
Liang, Taizhen
Wen, Jiayong
Lin, Wanying
Qiu, Jiayin
Liu, Shuwen
Li, Lin
FEBS LETTERS, 2018, 592 (13) : 2361 - 2377
[22] Neutralizing antibody to gp41 cluster II in defining stage of HIV-1 subtype E infection
Samransurp, K
Srisurapanon, S
Louisirirojanakul, S
Rattanasrithong, M
Wasi, C
JOURNAL OF CLINICAL VIROLOGY, 2003, 28 : S77 - S77
[23] Retraction Note: eliciting broadly neutralizing antibodies against HIV-1 that target gp41 MPER
D Han
H Habte
Y Qin
K Takamoto
C LaBranche
D Montefiori
MW Cho
Retrovirology, 11
[24] Structure-Based Design of a Protein Immunogen that Displays an HIV-1 gp41 Neutralizing Epitope
Stanfield, Robyn L.
Julien, Jean-Philippe
Pejchal, Robert
Gach, Johannes S.
Zwick, Michael B.
Wilson, Ian A.
JOURNAL OF MOLECULAR BIOLOGY, 2011, 414 (03) : 460 - 476
[25] A human monoclonal antibody to HIV-1 gp41 with neutralizing activity against diverse laboratory isolates
Cotropia, J
Ugen, KE
Kliks, S
Broliden, K
Broliden, PA
Hoxie, JA
Srikantan, V
Williams, WV
Weiner, DB
JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES AND HUMAN RETROVIROLOGY, 1996, 12 (03): : 221 - 232
[26] HIV-1 gp41 Core with Exposed Membrane-Proximal External Region Inducing Broad HIV-1 Neutralizing Antibodies
Wang, Ji
Tong, Pei
Lu, Lu
Zhou, Leilei
Xu, Liling
Jiang, Shibo
Chen, Ying-hua
PLOS ONE, 2011, 6 (03):
[27] Thermodynamics of peptide inhibitor binding to HIV-1 gp41
Cole, JL
Garsky, VM
BIOCHEMISTRY, 2001, 40 (19) : 5633 - 5641
[28] Tannin inhibits HIV-1 entry by targeting gp41
Lin Lü2
Lindsley F Kimball Research Institute
ActaPharmacologicaSinica, 2004, (02) : 87 - 92
[29] Inhibition of HIV-1 gp41 expression with hammerhead ribozymes
Fedoruk-Wyszomirska, Agnieszka
Szymanski, Maciej
Glodowicz, Pawel
Gabryelska, Marta
Wyszko, Eliza
Estrin, William J.
Barciszewski, Jan
BIOCHEMICAL JOURNAL, 2015, 471 : 53 - 66
[30] Tannin inhibits HIV-1 entry by targeting gp41
Lü, L
Liu, SW
Jiang, SB
Wu, SG
ACTA PHARMACOLOGICA SINICA, 2004, 25 (02) : 213 - 218

← 1 2 3 4 5 →